http://nnpub.org/index.php/PBS/issue/feed Journal of Advance Research in Pharmacy & Biological Science (ISSN: 2208-2360) 2019-06-06T17:47:22+00:00 Asif Khan editor@nnpub.org Open Journal Systems <p><strong>Journal of Advance Research in&nbsp;Pharmacy &amp; Biological Science</strong><em><strong>(ISSN: 2208-2360)</strong></em> is an emerging journal, publishing research in the field of pharmacy &amp; biological science.<strong> Journal of Advance Research in Pharmacy &amp; Biological Science(ISSN : 2208-2360)</strong> is an open access journal that publishes research in monthly frequency. We support and accept all articles related to the field of pharmaceutical, the latest research in medicines and types of equipment, biological science, health science etc.&nbsp;</p> <h1 style="text-shadow: 0 0 3px #34baeb;">Current Impact Factor : 3.340</h1> http://nnpub.org/index.php/PBS/article/view/742 Dual role of RNase A and Metosartan - Examination in invitro &invivo condition 2019-06-06T17:47:22+00:00 Eswari Beeram eshu.sonu@gmail.com <p>Metosartan consists of two components Metoprolol and telmisartan. Telmisartan inhibits RNase A in rat testes by uncompetitive inhibition where as Metoprolol forms DNA adducts and reduces sperm count. Metosartan decreases testes viability and sperm count was found to be high in metosartan treated rats compared to Metosartan +RNase A group. RNase A induces Netosis in both invivo and invitro condition in both RNase treated group and as well as RNase A+ Metosartan. Deep cold storage of mitochondria induces expression of cyt P450gene in testes mitochondria but not in sperm.</p> 2019-06-06T00:00:00+00:00 Copyright (c) 2019 Journal of Advance Research in Pharmacy & Biological Science (ISSN: 2208-2360)