EVALUATION OF ANTIMICROBIAL AND BIOACTIVE POTENTIALS OF TELFAIRIA OCCIDENTALIS ON MICROORGANISMS
DOI:
https://doi.org/10.53555/nnas.v8i1.1272Keywords:
T. occidentalis, phytochemical, ethanol, acetone, antimicrobialAbstract
The intensification of numerous deadly diseases like infections by multidrug-resistant bacteria suggests re-inventing the wheel on drug discovery. Indeed, countless disparate studies have underscored substitutes for combating the effects of antibiotic resistance. For many decades, plants have assumed an essential alternative medicine, demonstrated to be effective in human healthcare. The use of plants as alternative antibiotics in controlling some illnesses has attracted considerable research attention. The present paper investigates the phytochemical contents and the antimicrobial action of T. occidentalis on microorganisms. In particular, the study examined its effect on Candida albicans, Staphylococcus aureus, and Pseudomonas aeruginosa. The outcome of the phytochemical analysis performed on the seed and leaf of T. occidentalis indicated the presence of tannin, alkaloids, steroids, flavonoids, saponins, and phenol. However, it was found that phenol and tannins were primarily deposited in the plant's seed. Similarly, the antimicrobial analysis showed that S. aureus was more susceptible to the acetone, ethanol, and hot aqueous extracts of T. occidentalis. Furthermore, Candida albicans and Pseudomonas aeruginosa showed sensitivity to acetone and ethanol but did not react to the hot aqueous extracts. The study's findings reveal that the biological responses elicited by T. occidentalis aqueous extracts support the plant's historical use as an alternative antibiotic.
References
Abdulmalik, O., Oladapo, O. O., & Bolaji, M. O. (2016). Effect of aqueous extract of Vernonia amygdalina on atherosclerosis in rabbits. ARYA Atherosclerosis, 12(1).
Adetutu, A., Morgan, W. A., & Corcoran, O. (2011). Ethnopharmacological survey and in vitro evaluation of wound-healing plants used in South-western Nigeria. Journal of Ethnopharmacology, 137(1). https://doi.org/10.1016/j.jep.2011.03.073
Adeyeye, O. O., Onadeko, B. O., Ogunleye, O., Bamisile, R. T., & Olubusi, A. (2011). The use of complementary and alternative medicine by asthma patients receiving care in an urban tertiary center in Nigeria. Int J Biol Med Res, 2(4).
Adisa, W. A., Otamere, H. O., Osifo, C. U., Ediangbe, A. P., Ogarah, P. A., Aigbogun, T. O., & Info, A. (2012). Plasma glucose in Telfairia occidentalis treated rats. Advances in Applied Science Research, 3(3).
Aira, A., Fehér, C., Rubio, E., & Soriano, A. (2019). The intestinal microbiota as a reservoir and a therapeutic target to fight multi-drug-resistant bacteria: a narrative review of the literature. In Infectious Diseases and Therapy (Vol. 8, Issue 4). https://doi.org/10.1007/s40121-019-00272-7
Airaodion, A. I., Ibrahim, A. H., Ogbuagu, U., Ogbuagu, E. O., Awosanya, O. O., Akinmolayan, J. D., Njoku, O. C., Obajimi, O. O., Adeniji, A. R., & Adekale, O. A. (2019). Evaluation of phytochemical content and antioxidant potential of Ocimum gratissimum and telfairia occidentalis leaves. Asian Journal of Research in Medical and Pharmaceutical Sciences. https://doi.org/10.9734/ajrimps/2019/v7i130110
Aisida, S. O., Ugwu, K., Nwanya, A. C., Bashir, A. K. H., Uba Nwankwo, N., Ahmed, I., & Ezema, F. I. (2019). Biosynthesis of silver oxide nanoparticles using leave extract of Telfairia Occidentalis and its antibacterial activity. Materials Today: Proceedings, 36. https://doi.org/10.1016/j.matpr.2020.03.005
Ajani, R., & Akinyemi, A. (2016). Telfairia occidentalis Leaf and Seed Extract as Possible Preventive and Therapeutic Agents for Induced Benign Prostatic Hyperplasia. European Journal of Medicinal Plants, 12(1). https://doi.org/10.9734/ejmp/2016/22856
Ajao, M. Y., & Akindele, A. J. (2013). Anxiolytic and sedative properties of hydroethanolic extract of Telfairia occidentalis leaves in mice. Revista Brasileira de Farmacognosia, 23(2). https://doi.org/10.1590/S0102-695X2012005000138
Akindele, A. J., Ajao, M. Y., Aigbe, F. R., & Enumah, U. S. (2013). Effects of telfairia occidentalis (fluted pumpkin; Cucurbitaceae) in mouse models of convulsion, muscle relaxation, and depression. Journal of Medicinal Food, 16(9). https://doi.org/10.1089/jmf.2012.0211
Akter, S., Lee, S. Y., Siddiqi, M. Z., Balusamy, S. R., Ashrafudoulla, M., Rupa, E. J., & Huq, M. A. (2020). Ecofriendly synthesis of silver nanoparticles by Terrabacter humi sp. nov. and their antibacterial application against antibiotic-resistant pathogens. International Journal of Molecular Sciences, 21(24). https://doi.org/10.3390/ijms21249746
Al-Salami, A. K., & Al-Abbasy, A. J. (2020). Antibiotic resistance among Gram-negative bacilli isolated from different clinical samples in Al-Sader Medical City. Drug Invention Today, 13(5).
Ala, A. O., Ojo, O. A., Enikuomehin, C. A., Ajani, G. O., Olamoyegun, M. A., Akinlade, A. T., & Olabode, O. R. (2020). Prevalence and Determinants of Complementary and Alternative Medicine (CAM) Use among Diabetes Patients in Southwestern Nigeria. West African Journal of Medicine, 37(5).
Alara, O. R., Abdurahman, N. H., Ukaegbu, C. I., & Kabbashi, N. A. (2019). Extraction and characterization of bioactive compounds in Vernonia amygdalina leaf ethanolic extract comparing Soxhlet and microwave-assisted extraction techniques. Journal of Taibah University for Science, 13(1). https://doi.org/10.1080/16583655.2019.1582460
Albejo, B., Endale, M., Kibret, B., & Anza, M. (2015). Phytochemical investigation and antimicrobial activity of leaves extract of Vernonia auriculifera Hiern. Journal of Pharmacy and Pharmacognosy Research, 3(6).
Ali, M., Yahaya, A., Zage, A., & Yusuf, Z. (2017). In-vitro Antibacterial Activity and Phytochemical Screening of Psidium guajava on Some Enteric Bacterial Isolates of Public Health Importance. Journal of Advances in Medical and Pharmaceutical Sciences, 12(3). https://doi.org/10.9734/jamps/2017/31126
Ali, S., Ullah, S., Paudyal, V., Ali, M., Khalid Tipu, M., & Ur-Rehman, T. (2020). Complementary and Alternative Medicines for the Treatment of Hepatitis C: Perspectives of Users and CAM Practitioners. Evidence-Based Complementary and Alternative Medicine, 2020. https://doi.org/10.1155/2020/3932690
Aliyu, U. M., Awosan, K. J., Oche, M. O., Taiwo, A. O., Jimoh, A. O., & Okuofo, E. C. (2017). Prevalence and correlates of complementary and alternative medicine use among cancer patients in Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. Nigerian Journal of Clinical Practice, 20(12). https://doi.org/10.4103/njcp.njcp_88_17
Aregheore, E. M. (2011). Nutritional value and inherent anti-nutritive factors in four indigenous edible leafy vegetables in human nutrition in Nigeria: A Review. Journal of Food Resource Science, 1(1). https://doi.org/10.3923/jfrs.2012.1.14
Asif, M. (2013). The anticonvulsant potential of some medicinal plants and their beneficial properties. TANG [Humanitas Medicine], 3(4). https://doi.org/10.5667/tang.2013.0012
Atabo, S., Umar, I. A., James, D. B., & Mamman, A. I. (2016). Sickled Erythrocytes reversal and membrane-stabilizing compounds in Telfairia occidentalis. Scientifica, 2016. https://doi.org/10.1155/2016/1568061
Avner, B. S., Fialho, A. M., & Chakrabarty, A. M. (2012). Overcoming drug resistance in multi-drug resistant cancers and microorganisms. Bioengineered, 3(5). https://doi.org/10.4161/bioe.21130
Aworunse, O. S., Bello, O. A., Popoola, J. O., & Obembe, O. O. (2018). Pharmacotherapeutic properties of Telfairia occidentalis Hook F.: A systematic review. In Pharmacognosy Reviews (Vol. 12, Issue 24). https://doi.org/10.4103/phrev.phrev_12_18
Baars, E. W., Zoen, E. B. Van, Breitkreuz, T., Martin, D., Matthes, H., Schoen-Angerer, T. Von, Soldner, G., Vagedes, J., Wietmarschen, H. Van, Patijn, O., Willcox, M., Flotow, P. Von, Teut, M., Ammon, K. Von, Thangavelu, M., Wolf, U., Hummelsberger, J., Nicolai, T., Hartemann, P., … Huber, R. (2019). The contribution of complementary and alternative medicine to reduce antibiotic use: A narrative review of health concepts, prevention, and treatment strategies. In Evidence-based Complementary and Alternative Medicine (Vol. 2019). https://doi.org/10.1155/2019/5365608
Calonico, C., Pesavento, G., Delfino, V., Forni, S., & Lo Nostro, A. (2018). Prevalence of Antibiotic Resistance in Enterococci: A 14 Year Survey. Journal of Food and Nutrition Research, 6(10). https://doi.org/10.12691/jfnr-6-10-3
Carro, L. (2018). Protein-protein interactions in bacteria: A promising and challenging avenue towards discovering new antibiotics. In Beilstein Journal of Organic Chemistry (Vol. 14). https://doi.org/10.3762/bjoc.14.267
Chaman, S., Sharma, G., & Reshi, A. K. (2013). Study of antimicrobial properties of Catharanthus roseus by agar well diffusion method. International Research Journal of Pharmaceutical and Applied Sciences, 3(5).[28] Dahake, P. R., & Kamble, S. I. (2014). Investigatory study on antimicrobial activity and phytochemical screening of Butea monosperma linn. Biosciences Biotechnology Research Asia, 11(3). https://doi.org/10.13005/bbra/1571
De Freitas, L. C. (2017). WHO (2017) Global priority list of antibiotic-resistant bacteria guides research, discovery, and development of new antibiotics. Cadernos de Pesquisa, 43(148).
Deepika Tekaday, Reena Antony, & Sourabh Jain. (2020). Antimicrobial, antioxidant, and phytochemical investigation of Thuja occidentalis (Arborvitae) leave extract. GSC Biological and Pharmaceutical Sciences, 12(3). https://doi.org/10.30574/gscbps.2020.12.3.0292
Dias, L. D., Blanco, K. C., Mfouo-Tynga, I. S., Inada, N. M., & Bagnato, V. S. (2020). Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy. In Journal of Photochemistry and Photobiology C: Photochemistry Reviews (Vol. 45). https://doi.org/10.1016/j.jphotochemrev.2020.100384
Duru, C., Nduka, I., & Obikeze, O. (2020). Complementary and alternative medicine used for the treatment of acute illnesses in children living in Yenagoa, Nigeria. Journal of Complementary and Alternative Medical Research. https://doi.org/10.9734/jocamr/2019/v8i430127
El Hajj, M., & Holst, L. (2020). Herbal medicine use during pregnancy: A literature review with a particular focus on Sub-Saharan Africa. In Frontiers in Pharmacology (Vol. 11). https://doi.org/10.3389/fphar.2020.00866
Eltayeb, I. M., & Hamid, A. S. (2017). Phytochemical screening and antimicrobial activity of thuja occidentalis seeds extract against the isolated common skin infecting microorganisms. International Journal of Pharmacy and Pharmaceutical Sciences, 9(10). https://doi.org/10.22159/ijpps.2017v9i11.21310
Eseyin, O. A., Benedict, U., Thomas, P. S., Etim, I., Essien, E., Johnson, E., Ebong, A., Munavvar, Z., Ahmad, A., Sheryar, A., & Akpan, U. (2018). Isolation and characterization of antioxidant constituents of the fruit of telfairia occidentalis hook f (Cucurbitaceae). Tropical Journal of Pharmaceutical Research, 17(10). https://doi.org/10.4314/tjpr.v17i10.9
Eseyin, O. A., Sattar, M. A., & Rathore, H. A. (2014). A review of the pharmacological and biological activities of the aerial parts of Telfairia occidentalis Hook. f. (Cucurbitaceae). In Tropical Journal of Pharmaceutical Research (Vol. 13, Issue 10). https://doi.org/10.4314/tjpr.v13i10.28
Eseyin, O. A., Sattar, M. A., Rathore, H. A., Aigbe, F., Afzal, S., Ahmad, A., Lazhari, M., & Akthar, S. (2018). GC-MS and HPLC profiles of phenolic fractions of the leaf of Telfairia occidentalis. Pakistan Journal of Pharmaceutical Sciences, 31(1).
Ezeome, E. R., & Anarado, A. N. (2007). Cancer patients use complementary and alternative medicine at the University of Nigeria Teaching Hospital, Enugu, Nigeria. BMC Complementary and Alternative Medicine, 7. https://doi.org/10.1186/1472-6882-7-28
Frattari, A., Savini, V., Polilli, E., Di Marco, G., Lucisano, G., Corridoni, S., Spina, T., Costantini, A., Nicolucci, A., Fazii, P., Viale, P., & Parruti, G. (2019). Control of Gram-negative multi-drug resistant microorganisms in an Italian ICU: Rapid decline due to a multifaceted intervention, including conservative use of antibiotics. International Journal of Infectious Diseases, 84. https://doi.org/10.1016/j.ijid.2019.04.002
Guo, Y., Song, G., Sun, M., Wang, J., & Wang, Y. (2020). Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus. In Frontiers in Cellular and Infection Microbiology (Vol. 10). https://doi.org/10.3389/fcimb.2020.00107
Hamayun, M., Khan, S. A., Kim, H. Y., Chae, I. N., & Lee, I. J. (2006). Traditional knowledge and ex situ conservation of some threatened medicinal plants of Swat Kohistan, Pakistan. International Journal of Botany, 2(2). https://doi.org/10.3923/ijb.2006.205.209
Ichim, D. L., Duceac, L. D., Marcu, C., Iordache, A. C., Ciomaga, I. M., Luca, A. C., Goroftei, E. R. B., Mitrea, G., Damir, D., & Stafie, L. (2019). Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms. Revista de Chimie, 70(10). https://doi.org/10.37358/rc.19.10.7635
Igbeneghu, O. A., & Abdu, A. B. (2014). Multiple antibiotic-resistant bacteria on fluted pumpkin leaves, a herb of therapeutic value. Journal of Health, Population, and Nutrition, 32(2). https://doi.org/10.3329/jhpn.v32i2.2611
James, P. B., Wardle, J., Steel, A., & Adams, J. (2018). Traditional, complementary and alternative medicine use in Sub-Saharan Africa: A systematic review. BMJ Global Health, 3(5). https://doi.org/10.1136/bmjgh-2018-000895
James SA, Omwirhiren REM, Joshua IA, D. I. (2016). Antidiabetic properties and phytochemical studies of ethanolic leaf extracts of Murraya koenigii and Telfairia occidentalis on Alloxan-induced diabetic albino rats. Advances in Life Science and Technology, 49(January).
Jamshidi-Kia, F., Lorigooini, Z., & Amini-Khoei, H. (2018). Medicinal plants: History and future perspective. In Journal of HerbMed Pharmacology (Vol. 7, Issue 1). https://doi.org/10.15171/jhp.2018.01
Jimoh, T. O. (2018). Enzymes inhibitory and radical scavenging potentials of two selected tropical vegetables (Moringa oleifera and Telfairia occidentalis) leaves relevant to type 2 diabetes mellitus. Revista
Brasileira de Farmacognosia, 28(1). https://doi.org/10.1016/j.bjp.2017.04.003
Johnson, M., Kolawole, O. S., & Olufunmilayo, L. A. (2015). Phytochemical analysis, in vitro evaluation of the antioxidant and antimicrobial activity of methanolic leaf extract of Vernonia amygdalina (bitter leaf) against Staphylococcus aureus and Pseudomonas aeruginosa. International Journal of Current Microbiology and Applied Sciences, 4(5).
Kamatenesi-Mugisha, M., Oryem-Origa, H., Odyek, O., & Makawiti, D. W. (2008). Medicinal plants used to treat fungal and bacterial infections in and around Queen Elizabeth Biosphere Reserve, western Uganda. African Journal of Ecology, 46(SUPPL. 1). https://doi.org/10.1111/j.1365-2028.2008.00935.x
Kayanja, F. I. B. (2008). Biodiversity in inhabited areas of Eastern Africa. African Journal of Ecology, 46(1).
Kayode, A. A. A., & Kayode, O. T. (2011). Some medicinal values of telfairia occidentalis: A review. American Journal of Biochemistry and Molecular Biology, 1(1). https://doi.org/10.3923/ajbmb.2011.30.38
Kayode, O. T., Kayode, A. A., & Odetola, A. A. (2009). The therapeutic effect of Telfairia occidentialis on protein-energy malnutrition-induced liver damage. Research Journal of Medicinal Plant, 3(3). https://doi.org/10.3923/rjmp.2009.80.92
Kumar, G., Jalaluddin, M., Rout, P., Mohanty, R., & Dileep, C. L. (2013). Emerging trends of herbal care in dentistry. In Journal of Clinical and Diagnostic Research (Vol. 7, Issue 8). https://doi.org/10.7860/JCDR/2013/6339.3282
Lage, O. M., Ramos, M. C., Calisto, R., Almeida, E.%
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