Preparation and Diagnosis of New Azo - Barbiturate Dyes
DOI:
https://doi.org/10.53555/nnas.v5i12.575Keywords:
Barbituric acid, thymol, quinol, phenlenediamineAbstract
The research includes the preparation of new azo-barbiturate dyes derived from shiff bases prepared by reaction Barbituric acid & phenlenediamine and repellency bases by means of double-reaction of repellant bases with different phenolic compounds. These compounds were diagnosed using infrared techniques, ultraviolet-visible radiation, NMR proton and thin layer chromatography. All barbiturate dyes had absorption between (273 – 310) nm and showed hypsochromic shift from the corresponding azo dyes. The crystal structures of barbiturate dyes indicated that barbiturate ring is sterically hindered by phenol rings .
References
B. Dickey & A. R. Gray. "Barbituric acid". Org. Synth.,(1943), Coll. Vol., 2, p. 60 .
.Kauffman, George B. "Adolf von Baeyer and the naming of barbituric acid," Journal of Chemical Education, (1980), 57 : 222–223.
Boyd E M, Pearl M. "Can nalorphine hydrochloride prevent respiratory depression and death from overdose of barbiturates" , Canadian Medical Association Journal, (1955), 73(1):35-8.
Koppanyi T, Fazekas J F. "Acute Barbiturate Poisoning Analysis and Evaluation of Current Therapy[J]. American Journal of the Medical Sciences", (1950), 220(5):559-576
Shulman A, Shaw F H, Cass N M, et al. "A New Treatment of Barbiturate Intoxication"J. British Medical Journal, (1955), 1(4924):1238-44.
Bateman C H. "BARBITURATE POISONING" J. Lancet, (1963), 282(7303):357.
A khadim ," synthesis of new azo dyes via suzuki coupling ", (2014) .college of science 12 (20), 66-72
"Barbiturates". Archived from the original on 7 November 2007. Retrieved 2007-10-31, "Dorlands Medical Dictionary:hypnotic". Mercksource.com. Archived from the originalon ,(2008),12-11.
Brunton, Laurence L.; Lazo, John S.; Lazo Parker, Keith L.. "17: Hypnotics and Sedatives". Goodman & Gilman's The Pharmacological Basis of Therapeutics", (2006) , (11th ed.).
Mendels, J. "Criteria for selection of appropriate benzodiazepine hypnotic therapy". (September 1991). J Clin Psychiatry. 52. Suppl: 42–6
Glass, J.; Lanctôt, K. L.; Herrmann, N.; Sproule, B. A.; Busto, U. E. "Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits".(November 2005). BMJ. 331 (7526).
Arulmurugan S, Kavitha PH, Venkatraman RP ." Biological activities of Schiff base and its complexes: a review ". Rasayan J Chem . ,(2010) , 3(3):385–410.
Przybylski P, Huczy?ski A, Pyta K, Brzezinski B, Bartl F." Biological properties of Schiff bases and azo derivatives of phenols". Curr Org Chem 2009, 13: 124–148 .
Xu,H. and Zeng,X. "Synthesis of diaryl-azo derivatives as potential antifungal agents ".Bio org.Med.Chem.Lett. ,(2010) ,20, 4193-4195 .
Hatice K."Synthesis & spectral characteerisation of novel azo-azomethine dyes ", Turk.J.Chem. , (1999) , 23,67-71 .
Janeczek H, Sek D, Ostrowski S. " Similarities and differences between azomethines and ketimines ", Spectrochim Acta A Mol Biomol Spectrosc, (2007) , 66,1030-41.
Meghasham N. N. "Synthesis, Characterization & Antimicrobial Activities of Substituted 2, 5-Disubstituted Phenyl-6-Substituted Phenyl Sulfonamide / Azomethine / Azo. ", IJARCS ,( 2014) , 1, 70-86 .
S. Patai, Ed., "The Chemistry of the Carbon-Nitrogen Double Bond", J. Wiley & Sons, (1970), London .
Muhammad A. A., Karamat M., "Synthesis, Characterization and Biological Activity of Schiff Bases" , IPCBEE ,(2011) , 10 , 1-7 .
C. J. Patil et al. , " Synthesis & characterization of ketimines from 1- acetyl naphthalene with derivatives of aniline ", Der Pharma Chemica, (2016) , 8 (1) , 99-103 .
C. J. Patil and C. A. Nehete , " Synthesis & characterization of ketimines from 5-Chloro-4-methyl-2-hydroxy-acetophenone with disubstituted anilines " , Der Pharma Chemica, (2015) , 6(10) , 1-6 .
A. Saxena , "Synthesis and characterization of schiff base salicylaldehyde and thiohydrazones and its metal complexes " , Pelagia Research Library, (2013) , 4(4):152-154 .
Prakash, C.R., Raja, S., "Synthesis and Antimicrobial Activities of Some Novel Schiff Bases of 5-Substituted Isatin Derivatives ", Rasayan Journal of Chemistry, (2009) , 2, 960- 968.
SANDRA S. & DOO Aura. ," SYNTHESIS AND STRUCTURE OF VANILLIN AZOMETHINES" , CI&CEQ ,(2009) , 15 (4) 279?281 .
R.K. Agarwal, S. Prasad, Bioinorg , "Synthesis, Characterization & Antimicrobial Activities of azo methines of 3-methoxy-4-butoxy benzaldehyde ", Chem. Appl. , (2005), 3, 271-288 .
Furniss.S.Brian , Vogels textbook of practical organic chemistry " , 5th edition , John Wiley & Sons. Inc. , NY ,(1989 ).
Abdullah J.Kadim and Ali G.Kadhim" Synthesis & characterization some of ?, ? – unsaturated aliphatic ketones derivatives " , AL-Qadisiyah Journal for science, (2010) , 15 ,2, 45-62 .
Basser,M.A. & V.D.Phule , "Synthesis & antimicrobial activity of some new Schiff bases " , Orient.J.CHem. , (2000) , 16 , 553 .
R.M.Silverstein , " Spectrometric identification of organic compounds" , 5th edition ,Wiley , NY ,(1991).
Schraml, Jan; Bellama, Jon M. ," Two-Dimensional NMR Spectrocopy" New York: Wiley. , (1988) , pp. 28–33, 49–50
Wadher.S.J. , Puranik M.P. &Karande N.A. ,"Synthesis & Biological evalution sciff base of dapsone &their derivative as antimicrobial agents", Inter.J.Pharm.Tech.Res. , (2009) , 1 , 22-33 .
Jufe, G. S. "New hypnotics: perspectives from sleep physiology". Vertex (July–August 2007). 18 (74): 294–9 .
Löscher, W.; Rogawski, M. A. "How theories evolved concerning the mechanism of action of barbiturates".(2012). Epilepsia. 53: 12–25.
Huedo-Medina, T. B.; Kirsch, I.; Middlemass, J.; Klonizakis, M.; Siriwardena, A. N. "Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration"(17 December 2012) , BMJ. 345: e8343.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Terms & Condition
Submission -
Author can submit the manuscript through our online submission process or email us at the designated email id in contact details.
The other mode of submission not accepted than online and email.
Before submission please read the submission guidelines.
NN Publication accepts only article submitted in pdf/doc/docx/rtf file format. Another format except given file formats will no be considered .
Author will be responsible for the error mistakes in the submission files. The minor changes can be done without any cost after publication. But for major changes NN Publication may charges you the editing charges.
Publication (Online) -
The online publication is scheduled on last date of every month, but it can be delayed by 24 to 48 hours due to editorial process if huge number of articles comes to publish in single issue.
Automatic notificatation email will be sent to the all users on publication of an issue, so its author’s duty to check their email inbox or SPAM folder to get this notification.
After publication of article author can not withdraw their article.
If editor’s found any issue after publication of article then the NN Publication have the authority to remove the article from online website.
No refund will be provided after online publication of article.
Publication (Print) -
The print copy publication are sent as per the author’s request after 2 weeks of online publication of that issue.
NN Publication will ship the article by India Post and provide the consignment number on dispatch of print copy.
NN Publication follows all the guidelines of delivery provided by IndiaPost and hence not responsible for delay in delivery due to any kind of reasons.
Refund of hard copy will not be provided after dispatch or print of the journal.
NN Publication will be responsible for raise a complain if there is any issue occurs in delivery, but still will not be responsible for providing the refund.
NN Publication will be responsible to resend the print copy only and only if the print copy is lost or print copy is damaged in delivery / or there is delay more than 6 months.
According to India Post the delivery should be completed with in 1-3 weeks after dispatch of articles.
Privacy Policy-
NN Publicationl uses the email ids of authors and editors and readers for sending editorial or publication notification only, we do not reveal or sell the email ids to any other website or company.
