The Estimation of Glomerular Filtration Rate (GFR) for Renal Split Function with 99mTc-DTPA
DOI:
https://doi.org/10.53555/nnas.v2i11.674Keywords:
glomerular filtration, Tc-DTPA, renal splitAbstract
Introduction: To study the variation of kidney counts, uptake and Glomerular filtration rate with renal split function, 27 patient’s renogram data were taken. Therefore, toinvestigate of glomerular filtration rate (GFR) for renal split function with 99mTc-DTPA.
Procedures: The injected dose was calibrated by the dose calibrator. About 3mCi 99mTc with DTPA are taken into the syringe. With the help of gamma camera,the pre syringe counts (in Kcpm units) and post syringe counts (Kcpm units) are measured. From the value ofpre syringe counts and post syringe counts,the net injected counts are measured. Then the patient is placed on the imaging beds and the detector of the gamma camera is placed on the suitable position. The gamma rays are counted by the detector of the gamma camera,in which emits from the kidney of the patients andthe display unit shows the curve time versus counts per minute, Renal split function, uptake, Glomerular filtraration rate, kidney depth, and time of maximum counts for left and right kidney respectively by automated software (Easy soft-Semence signature series) programm. Results: The renal split function were investigated in the range of (89.99~22.4) %for left kidney and also (99.6~6.377) %for right kidney. It was found that the range of uptake (%), (8.019~2.2236) %for left kidney and (7.765~1.19) %for right kidney. The GFR were found in the range of (72.4~20.4) ml/min for left kidney and also (70.9~3.937) for right kidney.
Conclusion: The GFR was linear relationship with renal split functions but linearly decreased with patient’s age. For majority patients, the calculated value of GFR were (20-30) (ml/min) and (40-50) (ml/min) in left and right kidney respectively. Therefore, majority patient wasaffected in cardiovascular disease (CVD)
References
Prigent A, Cosgriff P, Gates GF, Granerus G, Fine EJ, Itoh K, et al. Consensus report on quality control of quantitative measurements of renal function obtained from the renogram: International consensus committee from the Scientific Committee of Radionuclides in Nephrourology. Semin Nucl Med . 1999; 29: 146–159
Gates GFGlomerular filtration rate: Estimation from fractional renal accumulation of 99mTc-DTPA (stannous). AJR. 1982;138: 565–570
Russell CD, Bischoff PG, Kontzen F, Rowell KL, Yester MV, Lloyd LK, et al. Measurement of glomerular filtration rate using 99mTc-DTPA and the gamma camera: a comparison of methods. EurJ Nucl Med. 1985;10: 519–521.
Fawdry RM, Grueneward SM, Collins LT, Roberts AJ. Comparative assessment of techniques for estimation of glomerular filtration rate with Tc-99m-DTPA. Eur J Nucl Med. 1985; 11: 7–12.
Russell CD, Dubovsky EV. Gates method for GFR measurement [letters to the editor]. J Nucl Med. 1986;27: 1373– 1374.
Russell CD. Estimation of glomerular filtration rate using 99mTc-DTPA and the gamma camera. Eur J Nucl Med. 1987;12: 548–552.
Mulligan JS, Blue PW, Hasbargen JA. Methods for measuring GFR with technetium-99m-DTPA: an analysis of several common methods. J Nucl Med. 1990; 31: 1211–1219.
Goates JJ, Morton KA, Whooten WW, Greenberg HE, Datz FL, Handy JE, et al. Comparison of methods for calculating glomerular filtration rate: technetium-99m-DTPA scintigraphic analysis, protein-free and whole-plasma clearance of technetium-99m-DTPA and iodine-125-iothalamate clearance. J Nucl Med. 1990; 31: 424–429.
Duran E, Prigent A, Gaillard J. Comparison between 9 methods for estimation of glomerular filtration rate (GFR) with simultaneous injection of 51Cr-EDTA and 99mTc-DTPA. In: Taylor A Jr, Nally J, Thomsen H (eds), Radionuclides in Nephrourology, Reston, VA; Society of Nuclear Medicine. 1997; 112–120.
De Santo NG, Anastasio P, Cirillo M, Santoro D, Spitali L, Mansi L, et al. Measurement of glomerular filtration rate by the 99mTc-DTPA renogram is less precise than measured and predicted creatinine clearance. Nephron. 1999; 81: 136–140.
Itoh K, Tsushima S, Tsukamoto E, Tamaki N. Reappraisal of single-sample and gamma camera methods for determination of the glomerular filtration rate with 99mTc-DTPA. Ann Nucl Med. 2000; 14: 143–150.
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16: 31–41.
Brochner-Mortensen J. Routine methods and their reliability for assessment of glomerular filtration rate in adults with special reference to total [51Cr]EDTA plasma clearance. Dan Med Bull. 1978;25: 181–202.
Brochner-Mortensen J. Current status on assessment and measurement of glomerular filtration rate. Clin Physiol.1983;8: 1–17.
Levey AS. Use of measurements of GFR to assess the progression of renal disease. Semin Nephrol. 1989;9: 370–378.
Blaufox MD, Aurell M, Bubeck B, Fommei E, Piepsz A, Russell C, et al. Report of the Radionuclides in Nephrourology Committee on renal clearance. J Nucl Med. 1996;37: 1883–1890.
Goates, JJ,. Morton KA, Whooten WW, Greenberg HE, Datz FL, Handy JE. Comparison of methods for calculating glomerular filtration rate: technetium-99m-DTPA scinti-graphic analysis, protein-free and wholeplasma clearance of technetium-99m-DTPA and iodine-125-iothalamate clearance. NucL Med. 1990;31: 424-429.
Taylor A, Nally JV. Clinical applications of renal scintigraphy. Am. J. Roentgenol. AJR. 1995;164(1): 31-41.
Hackstein N, Buch T, Rau WS, Weimer R, Klett R. Split renal function measured by triphasic helical CT. Eur. J. Radiol. 2007;61: 303-309.
Yura T, Takamitsu Y, Yuasa S, Miki S, Takahashi N, Bandai H, Sumikura T, Uchida K, Tamai T, Matsuo H. Total and split renal function assessed by ultrasound Doppler techniques. Nephron. 1991;58: 37-41.
Daniel GB, Mitchell SK, Mawby D, Sackman JE, Schmidt D. Renal nuclear medicine: a review. Vet. Radiol. Ultrasound. 1999;40: 572-587.
Miyazaki C, Harada H, Shuke N, Okizaki A, Miura M, Hirano T. (99m)Tc-DTPA dynamic SPECT and CT volumetry for measuring split renal function in live kidney donors. Ann. Nucl. Med. 1999;24: 189-195.
Ritchie G, Wilkinson AG, Prescott RJ. Comparison of differential renal function using technetium-99m mercaptoacetyltriglycine (MAG3) and technetium-99m dimercaptosuccinic acid (DMSA) renography in a paediatric population. Pediatr. Radiol. 2008;38: 857-862.
Summerlin AL, Lockhart ME, Strang AM, Kolettis PN, Fineberg NS, Smith JK. Determination of split renal function by 3D reconstruction of CT angiograms: a comparison with gamma camera renography. AJR Am. J. Roentgenol. 2008; 191: 1552-1558.
Itoh K. 99mTc-MAG3: review of pharmacokinetics, clinical application to renal diseases and quantification of renal function. Ann. Nucl. Med. 2001;15: 179-90.
Moran JK. Technetium-99m-EC and other potential new agents in renal nuclear medicine. Semin. Nucl. Med.1999;29: 91-101.
Sodee DB, Early PJ. Technologyand interpretation of nuclear medicine procedures, second Edition, st. Louis, C.V. Mosby company.1975;520.
Atkins HL, Eckelman WC, Hauser W, Klopper JF, Richards P. Evaluation of glumerular fitration rate with 99mTc –DTPA . J Nucl Med. 1971;12:338.
Chowdhuri TK. Use of 99mTc –DTPA for measuring gastric emptying time . J Nucl Med. 1974;15:391-395.
Coats G, O’Brodovich H. Measurement of pulmonary epithetlial permeability with 99mTc –DTPA aerosol .Semin Nucl Med. 1986;16(4):275–284
Hauser W, Atkins HL, Nelson KG, Richards P. Technetium99mTc –DTPA: a new radiopharmaceuticals for brain and kidney scanning . Radiology . 1970; 94(3):679–684.
Cardiol J, Cerqueira MD et al. Recommendations for reducing radiation exposure in myocardial perfusion imaging. J Nucl Cardio. 2010; 17: 709-718.
Dorland's Medical Dictionary for Health Consumers, by Saunders; Saunders Comprehensive Veterinary Dictionary, 3 ed. 2007; McGraw-Hill Concise Dictionary of Modern Medicine, 2002 by The McGraw-Hill Companies.
ADAM Multimedia Encyclopedia, Available from http://pennstatehershey.adam.com/content.aspx?productId=117&pid=1&gid=007305
CardioSmart, American College of Radiology, Available from https://www.cardiosmart.org/healthwise/aa15/4102/aa154102
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