Formulation and Evaluation of Herbal Gel Containing Kigelia africana(lam.) Benth., Fruits Extract
DOI:
https://doi.org/10.53555/nnas.v2i4.680Keywords:
Kigelia africana(Lam.), Benth, aqueous extract, Carbapol 940, herbal Gel, skin irritation.Abstract
Herbal medicine has become an item of global importance both medicinal and economical. Although usage of these herbal medicines has increased, their quality, safety and efficiency are serious concerns in industrialized and developing countries. The present research has been undertaken with the aim to formulate and evaluate the herbal gel containing Kigelia africana(Lam.) Benth., fruits extract. The gel formulation was designed by using Carbapol 940, Kigelia africana(Lam.) Benth., fruits extract, propylene glycol, methyl paraben, propyl paraben and required amount of distilled water. The skin pH (6.8-7.1) was maintained by drop wise addition of Triethanolamine. The physicochemical Parameters of formulations (pH, Spreadibility, Stability etc.) were determined. Stability studies have carried out as per ICH guidelines for 3 months at different temperatures and humidity. The results showed that formulation ontaining Kigelia africana(Lam.) Benth., fruits extract Show better stability. Further formulations have studied for skin irritation on animal model (Rat) and result showed that there was no skin irritation to animals.
References
Dubey NK, Kumar R, Tripati P. Global promation of herbal medicines: India’s Opportunity. Curr Med 2004; 86: 37-41.
Grace OM, Light ME, Lindsey KI, Mulholland DA, van Staden J, Jager AK, Antibacterial activity and isolation of active compounds from fruit of the traditional African medicinal tree Kigelia africana, South Afr J Bot. 2002;68(1);220-222.
cragg GM and NEWMAN DJ, medicinal for the millennia, An n NY Acad, sci 2001, 953, 3-25.
Tzu L, Cheng W, Chia C, Shu H, Wang S. Luteolin Inhibits the Release of Glutamate in Rat Cerebrocortical Nerve Terminals. J Agric Food Chem 2011; 59 (15), 8458-66.
Guterres SS, Alves MP, Pohlamnn AR. Polymeric nanoparticles, nanospheres and nanocapsules for cutaneous applications. Drug Target Insights. 2007; 2147-157.
Allen L, V Jr. The Basics of Compounding. Int J Pharm Compd. 1999; 3: 385-389.
Weller PJ. Handbook of Pharmaceutical Excipients. American Pharmaceutical Association., Washington DC, 2003,p. 521-523.
Panchangula R, Salve PS, Thomas NS, Jain AK, Ramarao P. Transdermal delivery of naloxone: effect of water, propylene glycol, ethanol and their binary combinations on permeation through rat skin. Int J Pharm. 2001; 219: 95-105.
Sudipta D, Pallab KH, Goutam P. International Journal of PharmTech Research. 2011; 3:140-143.
Carl AB, Edward RA.Text book of clinical chemistry and molecular diagnostics.4th rev. ed. W.B Saunders Philadelphia; 2001.
Patel RP, Kamani R. Formulation optimization and evaluation of mometazone furoatecream. J Pharm Res. 2002; 2: 1565-1569.
Panigrahi L, Ghosal SK, Pattnaik S, Maharana L, Barik BB. Effect of permeation enhancers on the Release and permeation kinetics of Lincomycin Hydrochloride gel formulations through Mouse skin. Indian J Pharm Sci 2006; 205-211
Pandit JK, Bharathi D, Srinatha A, Ridhurkar DN, Singh S. Long acting ophthalmicformulation of indomethacin: Evaluation of alginate gel systems. Ind J Pharm Sci. 2007; 69: 37-40.
Das K, Dang R, Machale UM. The Pharma Review. 2010; 8:112.
Prakash RP, Rao R. J.pharmaceutical and clinical research. 2010; 3: 126-129.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Terms & Condition
Submission -
Author can submit the manuscript through our online submission process or email us at the designated email id in contact details.
The other mode of submission not accepted than online and email.
Before submission please read the submission guidelines.
NN Publication accepts only article submitted in pdf/doc/docx/rtf file format. Another format except given file formats will no be considered .
Author will be responsible for the error mistakes in the submission files. The minor changes can be done without any cost after publication. But for major changes NN Publication may charges you the editing charges.
Publication (Online) -
The online publication is scheduled on last date of every month, but it can be delayed by 24 to 48 hours due to editorial process if huge number of articles comes to publish in single issue.
Automatic notificatation email will be sent to the all users on publication of an issue, so its author’s duty to check their email inbox or SPAM folder to get this notification.
After publication of article author can not withdraw their article.
If editor’s found any issue after publication of article then the NN Publication have the authority to remove the article from online website.
No refund will be provided after online publication of article.
Publication (Print) -
The print copy publication are sent as per the author’s request after 2 weeks of online publication of that issue.
NN Publication will ship the article by India Post and provide the consignment number on dispatch of print copy.
NN Publication follows all the guidelines of delivery provided by IndiaPost and hence not responsible for delay in delivery due to any kind of reasons.
Refund of hard copy will not be provided after dispatch or print of the journal.
NN Publication will be responsible for raise a complain if there is any issue occurs in delivery, but still will not be responsible for providing the refund.
NN Publication will be responsible to resend the print copy only and only if the print copy is lost or print copy is damaged in delivery / or there is delay more than 6 months.
According to India Post the delivery should be completed with in 1-3 weeks after dispatch of articles.
Privacy Policy-
NN Publicationl uses the email ids of authors and editors and readers for sending editorial or publication notification only, we do not reveal or sell the email ids to any other website or company.
