Possibility of Selenium Nanoparticles Manufactured by Glycyrrhiza glabra Extract and - Irradiation to Suppress the Growth of Murine Tumor
DOI:
https://doi.org/10.53555/nnpbs.v5i2.693Keywords:
Glycyrrhiza glabra, selenium nanoparticles, Ehrlich carcinomaAbstract
Glycyrrhiza glabra (Gg) is used in traditional medicine. The present study examine the possibility of Gg root extract and selenium nanoparticles (SeNPs) fabricate by Gg extract and ?- irradiation to suppress the growth of murine tumors. Ehrlich ascite carcinoma cells and 4 groups of Swiss albino mice were used. Solid Ehrlich carcinoma (EC) was induced by intramuscular injection of 2.5x106 cells. Mice were gavages by Gg extract or SeNPs. Tumor size, serum TNF-?, IFN-?, Granzyme-B and Caspase-3 were evaluated. Cat, GSH, MDA, histopathological, apoptotic and necrotic examinations were studied in tumor tissues. Either Gg extract or SeNPs significantly inhibit tumor size, TNF-?, IFN-? and MDA. On the other hand, elevation in Caspase-3 activity and Granzyme-B were predicted. Meanwhile, the histopathological, apoptotic and necrotic examinations were context with the previous results. From previous we conclude that Gg extract or SeNPs have the possibility to suppress the growth of Ehrlich carcinoma.
References
Yang R, Wang L, Liu Y. 2014. Antitumor Activities of widely used Chinese Herb—Licorice. Chinese Herbal Medicines. p. 274–281.
Wang H, Zhang J, Yu H. 2007. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: Comparison with selenomethionine in mice. Journal of Free Radical Biology & Medicine. p. 1524–1533.
Soda K, Tanaka H, Esaki N. 2010. Biochemistry of physiologically active selenium compounds. In: Organic Selenium and Tellurium Compounds (1987). John Wiley & Sons. p. 349–365.
Kieliszek M, Blazejak S. 2013. Selenium: Significance, and outlook for supplementation. Nutrition. p. 713–718.
El-Merzabani MM, El-Aaser AA, Atia MA, El-Duweini AK, Ghazal AM. 1979. Screening system for Egyptian plants with potential anti-tumour activity. Journal of plant Medica. p. 150.
Ghoneum M, Badr El-Din NK, Noaman E, Tolentino L. 2008. Saccharomyces cerevisiae, the Baker’s Yeast, suppresses the growth of Ehrlich carcinoma-bearing mice. Cancer Immunology Immunotherapy. p. 581–592.
Yoshioka T, Kawada K. 1979. Lipid peroxidation in maternal and cord blood and protective mechanism against activated oxygen toxicity in the blood. American Journal of Obstetrics and Gynecology. p. 372–376.
Beutler E, Duron O. 1963. Improved method for the determination of blood glutathione. Journal of Laboratory and Clinical Medicine. p. 882–888.
Sinha AK. 1972. Colorimetric assay of catalase. Journal of Analytical and Biochemistry. p. 389–394.
Banchroft JD, Stevens A, Turner DR. 1996. Theory and Practice of Histological Techniques. 4th ed. Churchil Livingstone, New York, London, San Francisco, Tokyo.
Ribble D, Goldstein NB, Norris DA, Shellman YG. 2005. A simple technique for quantifying apoptosis in 96-well plates. BMC Biotechnology. p. 5–12.
Harnett DL, Horrell JF. 1998. Data, Statistics and Decision Models with Excel. John Wiley & Sons, INC. Chapter 10 (Analysis of Variance). p. 450–455.
Wang AZ, Langer R, Farokhzad OC. 2012. Nanoparticle delivery of cancer drugs. Annual Review of Medicine. p. 185–198.
Wadhwani SA, Shedbalkar UU, Singh R, Chopade BA. 2016. Biogenic selenium nanoparticles: current status and future prospects. Applied Microbiology and Biotechnology. p. 2555–2566.
Ann MB, Zigang D. 2015. Chemopreventive Effects of Glycyrrhiza glabra and Its Components. Current Pharmacology Reports. p. 60–71.
Abbasalipourkabir R, Salehzadeh A, Abdullah R. 2011. Cytotoxicity Effect of Solid Lipid Nanoparticles on Human Breast Cancer Cell Lines. Biotechnology. p. 528–533.
Hanafi N, Asmaa A. 2015. Role of Irradiated Tumor Cell Lysate Vaccine and Low Doses of Gamma Irradiation in Tumor Regression. International Scientific Research Journal. p. 1–7.
So YP, Eun JK, Hyun JC, Mi RS, Soon SL, Young HK, Myung SC, Ki WL, Jung HYP. 2014. Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted Glycyrrhiza glabra root. Nutrition Research and Practice. p. 257–266.
Savita B, Amarnath M. 2009. Dextran–doxorubicin/chitosan nanoparticles for solid tumor therapy. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. p. 415–425.
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