PROLACTIN AND HOSTILITY IN HOSPITALISED PATIENT AND HEALTHY WOMAN: A SYSTEMATIC REVIEW

Authors

  • Eldwin Laurenso Lomi Faculty of Medicine, Hang Tuah University, Indonesia

DOI:

https://doi.org/10.53555/nnmhs.v8i12.1481

Keywords:

Breastfeeding, Hostility, Maternal, Prolactin

Abstract

These maternal adaptations are the result of dynamic changes in key hormones during pregnancy and lactation, which act on neural circuits in the brain. Lactogenic hormones (for example, prolactin and its pregnancy-specific homolog, placental lactogen) are significant regulators of these processes, with receptors located in key brain areas controlling emotional behaviors and maternal reactions. Prolactin (PRL) receptors are most typically found in the hypothalamus, where females have the highest amounts of binding. It has been proven beyond doubt that the hypothalamus has a role in the control of aggressive behavior in humans. This notion is particularly plausible for women. However, some research suggests that there is no link between PRL levels and levels of rage or aggression. This could be due, at least in part, to the fact that the participants in the several research were of different sorts, as discussed in the following section. PRL is enhanced not only after giving birth, but also as a result of other occurrences. Increased PRL levels have been associated to a variety of factors, including but not limited to pregnancy, primary hyperthyroidism, medications, pituitary tumor, stress, anxiety, and pain. According to studies, hospitalized patients had greater prolactin levels than healthy people. Stress, depression, anxiety, and other mood disorders are all linked to high prolactin levels.

 

References

Rørvang MV, Nielsen BL, Herskin MS, Jensen MB. Prepartum Maternal Behavior of Domesticated Cattle: A Comparison with Managed, Feral, and Wild Ungulates. Front Vet Sci. 2018;5:45.

Bridges RS. Neuroendocrine regulation of maternal behavior. Front Neuroendocrinol. Januari 2015;36:178–96.

Delgado-Alvarado M, Tordesillas-Gutierrez D, Ayesa-Arriola R, Canal M, de la Foz VO-G, Labad J, et al. Plasma prolactin levels are associated with the severity of illness in drug-naive first-episode psychosis female patients. Arch Womens Ment Health [Internet]. 2019;22(3):367–73. Tersedia pada: https://doi.org/10.1007/s00737-018-0899-x

Leziak M, Niedobylski S, ?ak K, Skórzy?ska-Dziduszko K, Krasowska D. Prolactin–friendly lactation hormone or hostile cancerogenic factor? J Educ Heal Sport. 2019;9(9):247–52.

Ioachimescu AG, Fleseriu M, Hoffman AR, Vaughan III TB, Katznelson L. Psychological effects of dopamine agonist treatment in patients with hyperprolactinemia and prolactin-secreting adenomas. Eur J Endocrinol. 2019;180(1):31–40.

Puljic K, Herceg M, Tudor L, Pivac N. The association between prolactin concentration and aggression in female patients with schizophrenia. World J Biol Psychiatry. 2021;22(4):301–9.

Georgescu T, Swart JM, Grattan DR, Brown RSE. The prolactin family of hormones as regulators of maternal mood and behavior. Front Glob Women’s Heal. 2021;91.

Barry JA, Moran E, Parekh HS, Morewood T, Thomas M, Hardiman PJ. Prolactin and aggression in women with fertility problems. J Obstet Gynaecol [Internet]. 2014;34(7):605–10. Tersedia pada: http://europepmc.org/abstract/MED/25226401

Elgellaie A, Larkin T, Kaelle J, Mills J, Thomas S. Plasma prolactin is higher in major depressive disorder and females, and associated with anxiety, hostility, somatization, psychotic symptoms and heart rate. Compr Psychoneuroendocrinology [Internet]. 2021;6:100049. Tersedia pada: https://www.sciencedirect.com/science/article/pii/S2666497621000230

Herceg M. Correlation between Prolactin and Symptom Profile in Acute Admitted Women with Recurrent Schizophrenia. Psychiatr Danub. 2020;32(3–4):367–72.

Haring R, Friedrich N, Völzke H, Vasan RS, Felix SB, Dörr M, et al. Positive association of serum prolactin concentrations with all-cause and cardiovascular mortality. Eur Heart J [Internet]. 7 Mei 2014;35(18):1215–21. Tersedia pada: https://doi.org/10.1093/eurheartj/ehs233

Brown RSE, Wyatt AK, Herbison RE, Knowles PJ, Ladyman SR, Binart N, et al. Prolactin transport into mouse brain is independent of prolactin receptor. FASEB J Off Publ Fed Am Soc Exp Biol. Februari 2016;30(2):1002–10.

Walsh RJ, Slaby FJ, Posner BI. A receptor-mediated mechanism for the transport of prolactin from blood to cerebrospinal fluid. Endocrinology. Mei 1987;120(5):1846–50.

Costa-Brito AR, Quintela T, Gonçalves I, Duarte AC, Costa AR, Arosa FA, et al. The Choroid Plexus Is an Alternative Source of Prolactin to the Rat Brain. Mol Neurobiol. April 2021;58(4):1846–58.

Brown RSE, Kokay IC, Herbison AE, Grattan DR. Distribution of prolactin-responsive neurons in the mouse forebrain. J Comp Neurol. Januari 2010;518(1):92–102.

Salais-López H, Agustín-Pavón C, Lanuza E, Martínez-García F. The maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain. PLoS One. 2018;13(12):e0208960.

Rajkumar RP. Prolactin and Psychopathology in Schizophrenia: A Literature Review and Reappraisal. Kirkpatrick B, editor. Schizophr Res Treatment [Internet]. 2014;2014:175360. Tersedia pada: https://doi.org/10.1155/2014/175360

Handelsman L, Kahn RS, Sturiano C, Rinaldi PJ, Gabriel S, Schmeidler JP, et al. Hostility is associated with a heightened prolactin response to meta-chlorophenylpiperazine in abstinent cocaine addicts. Psychiatry Res. 1998;80(1):1–12.

Gomes J, Sousa A, Lima G. Hyperprolactinemia: effect on mood? Eur Psychiatry. 2015;30(S1):1.

Barry JA, Moran E, Thomas M, Hardiman PJ. Prolactin and hostility in hospitalised patients and healthy women: A systematic review and meta-analysis. J Obstet Gynaecol (Lahore). 2015;35(5):499–507.

Kellner R, Buckman MT, Fava GA, Pathak D. Hyperprolactinemia, distress, and hostility. Am J Psychiatry. 1984;

Downloads

Published

2022-12-21

How to Cite

Laurenso Lomi, E. . (2022). PROLACTIN AND HOSTILITY IN HOSPITALISED PATIENT AND HEALTHY WOMAN: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 8(12), 19-24. https://doi.org/10.53555/nnmhs.v8i12.1481