ZONULIN LEVELS IN COMPLICATED PREGNANCY : A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.53555/nnmhs.v9i3.1570Keywords:
Body Mass Index, Compicated Pregnancy, Gestational Diabetes, Metabolic, ZonulinAbstract
Hepatocytes, enterocytes, adipose tissue, and immune cells are the primary sources of zonulin secretion. It is the major protein responsible for the regulation of tight junctions between intestinal epithelial cells. Stimulating the release of zonulin dissociates zonula occludens-1 protein from tight junctions, resulting in increased intestinal permeability. Intestinal barrier failure has a role in gestational diabetes and intrahepatic cholestasis of pregnancy pathogenesis (ICP). Dietary decisions have a significant impact on intestinal permeability and, as a result, the risk of developing metabolic diseases. The inability of this experiment to account for dietary components and make the appropriate adjustments to the results is a drawback. Throughout the course of our experiment, we noticed that plasma zonulin levels and body mass index (BMI) were positively associated. On the other hand, the conclusions of the studies conducted on pregnant women are debatable. Individuals with problems of pregnancy, such as gestational diabetes, have elevated zonulin levels. As we all know, gestational diabetes can lead to macrosomia, birth canal trauma, and a future risk of diabetes for both mother and child.
References
Chiba H, Osanai M, Murata M, Kojima T, Sawada N. Transmembrane proteins of tight junctions. Biochim Biophys Acta (BBA)-Biomembranes. 2008;1778(3):588–600.
Drago S, El Asmar R, Di Pierro M, Grazia Clemente M, Tripathi A, Sapone A, et al. Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol. 2006 Apr;41(4):408–19.
Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A, et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet [Internet]. 2000;355(9214):1518–9. Available from: https://www.sciencedirect.com/science/article/pii/S0140673600021693
Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, et al. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci. 2009;106(39):16799–804.
Sapone A, De Magistris L, Pietzak M, Clemente MG, Tripathi A, Cucca F, et al. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes. 2006;55(5):1443–9.
Fasano A. Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin. Ann N Y Acad Sci. 2000;915:214–22.
El Asmar R, Panigrahi P, Bamford P, Berti I, Not T, Coppa G V, et al. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology. 2002;123(5):1607–15.
Fasano A. Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci. 2012;1258(1):25–33.
Bawah AT, Seini MM, Yakubu YA, Ussher FA, Amoah BY, Alidu H. First trimester zonulin levels and adiposity as predictive indices of gestational diabetes mellitus. Int J Diabetes Dev Ctries. 2019;39:451–7.
Güvey H, Çelik S, Çal??kan CS, Y?lmaz Z, Y?lmaz M, Erten Ö, et al. How Do Serum Zonulin Levels Change in Gestational Diabetes Mellitus, Pregnancy Cholestasis, and the Coexistence of Both Diseases? Int J Environ Res Public Health. 2021 Nov;18(23).
Mokkala K, Tertti K, Rönnemaa T, Vahlberg T, Laitinen K. Evaluation of serum zonulin for use as an early predictor for gestational diabetes. Nutr Diabetes. 2017;7(3):e253–e253.
Mokkala K, Pellonperä O, Röytiö H, Pussinen P, Rönnemaa T, Laitinen K. Increased intestinal permeability, measured by serum zonulin, is associated with metabolic risk markers in overweight pregnant women. Metabolism. 2017;69:43–50.
Demir E, Ozkan H, Seckin KD, Sahtiyanc? B, Demir B, Tabak O, et al. Plasma zonulin levels as a non-invasive biomarker of intestinal permeability in women with gestational diabetes mellitus. Biomolecules. 2019;9(1):24.
Deniz CD, Ozler S, Say?n FK. Association of adverse outcomes of intrahepatic cholestasis of pregnancy with zonulin levels. J Obstet Gynaecol J Inst Obstet Gynaecol. 2021 Aug;41(6):904–9.
Wang W, Uzzau S, Goldblum SE, Fasano A. Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci. 2000;113(24):4435–40.
Ohlsson B, Roth B, Larsson E, Höglund P. Calprotectin in serum and zonulin in serum and feces are elevated after introduction of a diet with lower carbohydrate content and higher fiber, fat and protein contents. Biomed reports. 2017 Apr;6(4):411–22.
Houttu N, Mokkala K, Laitinen K. Overweight and obesity status in pregnant women are related to intestinal microbiota and serum metabolic and inflammatory profiles. Clin Nutr. 2018;37(6):1955–66.
Mokkala K, Röytiö H, Munukka E, Pietilä S, Ekblad U, Rönnemaa T, et al. Gut microbiota richness and composition and dietary intake of overweight pregnant women are related to serum zonulin concentration, a marker for intestinal permeability. J Nutr. 2016;146(9):1694–700.
American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2016;62–9.
Salzer L, Tenenbaum-Gavish K, Hod M. Metabolic disorder of pregnancy (understanding pathophysiology of diabetes and preeclampsia). Best Pract Res Clin Obstet Gynaecol [Internet]. 2015;29(3):328–38. Available from: https://www.sciencedirect.com/science/article/pii/S1521693414002119
Tomsett KI, Barrett HL, Dekker EE, Callaway LK, McIntyre DH, Dekker Nitert M. Dietary Fiber Intake Alters Gut Microbiota Composition but Does Not Improve Gut Wall Barrier Function in Women with Future Hypertensive Disorders of Pregnancy. Nutrients. 2020 Dec;12(12).
unningham FG, Leveno KJ, Bloom SL, Cunningham FG; Leveno KJ; Bloom SL; et al, Cunningham FG, Leveno KJ, et al. Williams Obstetri. 25th ed. New York: The McGraw-Hill Companies; 2020.
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