ASSOCIATION BETWEEN ALOPECIA AREATA AND COVID-19: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.53555/nnmhs.v9i3.1582Keywords:
alopecia areata, covid-19, hair lossAbstract
Objective: Alopecia areata (AA) is an inflammatory condition that damages hair cells and causes hair thinning. COVID-19-induced cytokine shift, antigen mimicry between the virus and hair follicles, and COVID-19-induced tissue destruction that revealed autoantigens. This study aims to review the existing literature systematically.
Materials and methods: A systematic search strategy was conducted across several electronic reference databases (PubMed, Cochrane Library, ProQuest) and included articles published between 2020–2023. Duplicate publications, review articles, and incomplete articles were excluded
Results: Database search yielded a total of 287 articles, which were systematically eliminated, leaving 6 relevant articles. Analyzed articles showed the incidence of alopecia areata (hair loss) in patient post-COVID-19.
Conclusion: COVID-19 is a disease that has very wide clinical manifestations. The mechanism of association between COVID-19 and alopecia areata is unclear. However, several factors can also have an effect, such as race, age, and gender.
References
Wu YC, Chen CS, Chan YJ. The outbreak of COVID-19: An overview. J Chinese Med Assoc. 2020;83(3):217–20.
Zaim S, Chong JH, Kankaranarayanan V, Hasky A. COVID-19 and Multiorgan Response. Curr Probl Cardiol [Internet]. 2020;45(1):1–9. Available from: http://journal.um-surabaya.ac.id/index.php/JKM/article/view/2203
Thakur V, Ratho RK, Kumar P, Bhatia SK, Bora I, Mohi GK, et al. Multi-organ involvement in covid-19: Beyond pulmonary manifestations. J Clin Med. 2021;10(3):1–19.
Wei KC, Yang CC. Hair loss and COVID-19. Dermatologica Sin. 2021;39(4):167–8.
Zhou C, Li X, Wang C, Zhang J. Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management. Clin Rev Allergy Immunol [Internet]. 2021;61(3):403–23. Available from: https://doi.org/10.1007/s12016-021-08883-0
Pratt CH, King LE, Messenger AG, Christiano AM, Sundberg JP. Alopecia areata. Nat Rev Dis Prim [Internet]. 2017;3:1–17. Available from: http://dx.doi.org/10.1038/nrdp.2017.11
Genovese G, Moltrasio C, Berti E, Marzano AV. Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives. Dermatology. 2021;237(1):1–12.
Mukherjee S, Kshirsagar M, Becker N, Xu Y, Weeks WB, Patel S, et al. Identifying long-term effects of SARS-CoV-2 and their association with social determinants of health in a cohort of over one million COVID-19 survivors. BMC Public Health [Internet]. 2022;22(1):1–10. Available from: https://doi.org/10.1186/s12889-022-14806-1
Phong CH, Babadjouni A, Nguyen C, Kraus CN, Mesinkovska NA. Not just thinning: A case of alopecia universalis after mild COVID-19. JAAD Case Reports [Internet]. 2022;25:1–3. Available from: https://doi.org/10.1016/j.jdcr.2022.04.024
Alkeraye S, Alrashidi A, Alotaibi NS, Almajli N, Alkhalifah B, Bajunaid N, et al. The Association Between Hair Loss and COVID-19: The Impact of Hair Loss After COVID-19 Infection on the Quality of Life Among Residents in Saudi Arabia. Cureus. 2022;2(10).
Hayran Y, Yorulmaz A, Gür G, Akta? A. Different hair loss patterns in two pediatric patients with COVID-19-associated multisystem inflammatory syndrome in children. Dermatol Ther. 2021;34(2):1–2.
Rinaldi F, Trink A, Giuliani G, Pinto D. Italian Survey for the Evaluation of the Effects of Coronavirus Disease 2019 (COVID-19) Pandemic on Alopecia Areata Recurrence. Dermatol Ther (Heidelb) [Internet]. 2021;11(2):339–45. Available from: https://doi.org/10.1007/s13555-021-00498-9
Kim J, Hong K, Gómez Gómez RE, Kim S, Chun BC. Lack of Evidence of COVID-19 Being a Risk Factor of Alopecia Areata: Results of a National Cohort Study in South Korea. Front Med. 2021;8(October):1–7.
Sgubbi P, Savoia F, Calderoni O, Longo R, Stinchi C, Tabanelli M. Alopecia areata in a patient with SARS-Cov-2 infection. Dermatol Ther. 2020;33(6):7–8.
Olayinka J (Jadé) T, Richmond JM. Immunopathogenesis of alopecia areata. Curr Res Immunol. 2021;2(January):7–11.
Lin X, Zhu L, He J. Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles. Front Cell Dev Biol. 2022;10(May):1–11.
Houschyar KS, Borrelli MR, Tapking C, Popp D, Puladi B, Ooms M, et al. Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms. Dermatology. 2020;236(4):271–80.
Christensen RE, Jafferany M. Association between alopecia areata and COVID-19: A systematic review. JAAD Int [Internet]. 2022;7:57–61. Available from: https://doi.org/10.1016/j.jdin.2022.02.002
Rossi A, Magri F, Michelini S, Sernicola A, Muscianese M, Caro G, et al. New onset of alopecia areata in a patient with SARS-CoV-2 infection: Possible pathogenetic correlations? J Cosmet Dermatol. 2021;20(7):2004–5.
Birkett L, Singh P, Mosahebi A, Dhar S. Possible Associations Between Alopecia Areata and COVID-19 Vaccination and Infection. Aesthetic Surg J. 2022;42(11):NP699–702.
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