SKIN DISEASE RELATED TO METABOLIC SYNDROME IN WOMEN: A SYSTEMATIC REVIEW

Authors

  • Yeyen Jani Sari Dabukke Faculty of Medicine, University of Methodist, Indonesia

DOI:

https://doi.org/10.53555/nnmhs.v9i3.1583

Keywords:

skin disorder, metabolic syndrome, mucocutaneous

Abstract

Objective: The metabolic syndrome" (MetS) refers to a group of clinical conditions that include abdominal obesity, hypertension, insulin resistance, and cholesterol. There was evidence that MetS is associated with a number of cutaneous disorders. This study aimed to review the correlation between metabolic syndrome and skin disease systematically.

Materials and methods: A systematic search strategy was conducted across several electronic reference databases (PubMed, Cochrane Library, ProQuest) and included articles published between 2019–2023. Duplicate publications, review articles, and incomplete articles were excluded

Results: Database search yielded 294 articles, which were systematically eliminated, leaving 6 relevant articles. Analyzed articles showed the association between diabetes mellitus and hidradenitis suppurativa.

Conclusion: Studies found a close connection between several cutaneous illnesses and MetS. Individuals who exhibit these conditions, which are indicators of MetS, should be questioned and, if necessary, tested for the condition.

References

Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL. Metabolic syndrome: pathophysiology, management, and modulation by natural compounds. Ther Adv Cardiovasc Dis [Internet]. 2017/06/22. 2017 Aug;11(8):215–25. Available from: https://pubmed.ncbi.nlm.nih.gov/28639538

Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, et al. Metabolic Syndrome: Updates on Pathophysiology and Management in 2021. Int J Mol Sci [Internet]. 2022 Jan 12;23(2):786. Available from: https://pubmed.ncbi.nlm.nih.gov/35054972

Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep [Internet]. 2018 Feb 26;20(2):12. Available from: https://pubmed.ncbi.nlm.nih.gov/29480368

Karadag AS, Lavery MJ. Skin and the metabolic syndrome. Vol. 36, Clinics in dermatology. United States; 2018. p. 1–2.

Ferdinando LB, Fukumoto PK, Sanches S, Fabricio LHZ, Skare TL. Metabolic syndrome and psoriasis: A study in 97 patients. Rev Assoc Med Bras. 2018;64(4):368–73.

Trong HN, Tat TN, Anh TTN, Uyen NP, Van TN, Hau KT, et al. Efficacy of adding oral simvastatin to topical therapy for treatment of psoriasis: The Vietnamese experience. Open Access Maced J Med Sci. 2019;7(2):237–42.

Abdelmawla MY, Esawy A, Khater E, Khalifa N. Insulin resistance in androgenetic alopecia and acne vulgaris. Egypt J Dermatology Venerol. 2019;39(2):83.

Chandak S, Singh A, Madke B, Jawade S, Khandelwal R. Acne Vulgaris and Metabolic Syndrome: A Possible Association. Cureus. 2022;14(Type 2).

Shalom G, Dreiher J, Kridin K, Horev A, Khoury R, Battat E, et al. Atopic dermatitis and the metabolic syndrome: a cross-sectional study of 116 816 patients. J Eur Acad Dermatology Venereol. 2019;33(9):1762–7.

Jørgensen AHR, Yao Y, Ghazanfar MN, Ring HC, Thomsen SF. Burden, predictors and temporal relationships of comorbidities in patients with hidradenitis suppurativa: a hospital-based cohort study. J Eur Acad Dermatology Venereol. 2020;34(3):565–73.

Leroith D. Pathophysiology of the metabolic syndrome: implications for the cardiometabolic risks associated with type 2 diabetes. Am J Med Sci. 2012 Jan;343(1):13–6.

Fatima F, Das A, Kumar P, Datta D. Skin and metabolic syndrome: An evidence based comprehensive review. Indian J Dermatol [Internet]. 2021 May 1;66(3):302–7. Available from: https://www.e-ijd.org/article.asp?issn=0019-5154

Davidovici BB, Sattar N, Prinz JC, Puig L, Emery P, Barker JN, et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol. 2010 Jul;130(7):1785–96.

Azfar RS, Gelfand JM. Psoriasis and metabolic disease: epidemiology and pathophysiology. Curr Opin Rheumatol [Internet]. 2008 Jul;20(4):416–22. Available from: https://pubmed.ncbi.nlm.nih.gov/18525354

Misitzis A, Cunha PR, Kroumpouzos G. Skin disease related to metabolic syndrome in women. Int J Women’s Dermatology [Internet]. 2019;5(4):205–12. Available from: https://doi.org/10.1016/j.ijwd.2019.06.030

Kartal D, Yildiz H, Ertas R, Borlu M, Utas S. Association between isolated female acne and insulin resistance: a prospective study. G Ital di dermatologia e Venereol organo Uff Soc Ital di dermatologia e Sifilogr. 2016 Aug;151(4):353–7.

Stefanadi EC, Dimitrakakis G, Antoniou CK, Challoumas D, Punjabi N, Dimitrakaki IA, et al. Metabolic syndrome and the skin: A more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients. Diabetol Metab Syndr [Internet]. 2018;10(1):1–11. Available from: https://doi.org/10.1186/s13098-018-0311-z

Miller IM, McAndrew RJ, Hamzavi I. Prevalence, Risk Factors, and Comorbidities of Hidradenitis Suppurativa. Dermatol Clin [Internet]. 2016;34(1):7–16. Available from: http://dx.doi.org/10.1016/j.det.2015.08.002

Seyed Jafari SM, Hunger RE, Schlapbach C. Hidradenitis Suppurativa: Current Understanding of Pathogenic Mechanisms and Suggestion for Treatment Algorithm. Front Med. 2020;7(March):18–20.

Garg A, Birabaharan M, Strunk A. Prevalence of type 2 diabetes mellitus among patients with hidradenitis suppurativa in the United States. J Am Acad Dermatol [Internet]. 2018;79(1):71–6. Available from: https://doi.org/10.1016/j.jaad.2018.01.014

Garg A, Malviya N, Strunk A, Wright S, Alavi A, Alhusayen R, et al. Comorbidity screening in hidradenitis suppurativa: Evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations. J Am Acad Dermatol [Internet]. 2022;86(5):1092–101. Available from: https://doi.org/10.1016/j.jaad.2021.01.059

Kohorst JJ, Kimball AB, Davis MDP. Systemic associations of hidradenitis suppurativa. J Am Acad Dermatol [Internet]. 2015;73(5):S27–35. Available from: http://dx.doi.org/10.1016/j.jaad.2015.07.055

Downloads

Published

2023-03-10

How to Cite

Jani Sari Dabukke, Y. (2023). SKIN DISEASE RELATED TO METABOLIC SYNDROME IN WOMEN: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(3), 37-41. https://doi.org/10.53555/nnmhs.v9i3.1583