THE ROLE OF DIETARY SUPPLEMENTS IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW

Authors

  • Nella Rossiyah Faculty of Medicine, University of Jambi, Indonesia

DOI:

https://doi.org/10.53555/nnmhs.v9i3.1619

Keywords:

Dietary Supplements, Inflammatory Bowel Disease, Probiotics, Vitamin D levels

Abstract

Recurrent episodes of gastrointestinal inflammation induced by an inappropriate immune response to gut bacteria characterize inflammatory bowel disease (IBD). The phrase "inflammatory bowel disease" refers to two distinct forms of idiopathic intestinal disease distinguished by their location and degree of gut wall involvement. Although Crohn disease is substantially more common in women than in men, ulcerative colitis appears to be equally common in both sexes. IBD is often frequent in affluent countries and cooler regions. It occurs when an excessively powerful immune response is generated in response to a normal stimulus, such as food or intestinal flora, in individuals who are genetically predisposed to developing the disorder. Diet significantly influences intestinal inflammation. Unbalanced meals can result in dysbiosis, which impairs the immune system of the host. The Mediterranean Diet is renowned for being anti-inflammatory and dysbiosis-preventing. Probiotics, butyrate, phosphatidylcholine, lactoferrin, palmitoylethanolamide, silymarin, and omega 3 should be introduced to the diet of the patient in order to stabilize the intestinal microbial population and reinforce the mucosal barrier, hence preventing or alleviating IBD symptoms. Intestinal inflammation is usually associated with vitamin D levels and gut flora. Constant study has demonstrated their link, therefore the prescription of probiotics and vitamin D is beneficial for IBD patients.

References

Dmochowska N, Wardill HR, Hughes PA. Advances in Imaging Specific Mediators of Inflammatory Bowel Disease. Int J Mol Sci. 2018 Aug;19(9).

Fauci AS, Jameson JL, Kasper D, et al. Harrison’s Principles of Internal Medicine 19th Edition. New York: McGraw-Hill Education; 2018.

Maaser C, Sturm A, Vavricka SR, Kucharzik T, Fiorino G, Annese V, et al. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis. 2019 Feb;13(2):144–64.

Colombel J-F, Shin A, Gibson PR. AGA Clinical Practice Update on Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: Expert Review. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2019 Feb;17(3):380-390.e1.

Su H-J, Chiu Y-T, Chiu C-T, Lin Y-C, Wang C-Y, Hsieh J-Y, et al. Inflammatory bowel disease and its treatment in 2018: Global and Taiwanese status updates. J Formos Med Assoc. 2019 Jul;118(7):1083–92.

Ghishan FK, Kiela PR. Vitamins and minerals in inflammatory bowel disease. Gastroenterol Clin. 2017;46(4):797–808.

Chicco F, Magrì S, Cingolani A, Paduano D, Pesenti M, Zara F, et al. Multidimensional impact of Mediterranean diet on IBD patients. Inflamm Bowel Dis. 2021;27(1):1–9.

Rossi RE, Whyand T, Murray CD, Hamilton MI, Conte D, Caplin ME. The role of dietary supplements in inflammatory bowel disease: a systematic review. Eur J Gastroenterol Hepatol. 2016;28(12):1357–64.

Romani A, Ieri F, Urciuoli S, Noce A, Marrone G, Nediani C, et al. Health effects of phenolic compounds found in extra-virgin olive oil, by-products, and leaf of Olea europaea L. Nutrients. 2019;11(8):1776.

Vitetta L, Vitetta G, Hall S. Immunological tolerance and function: associations between intestinal bacteria, probiotics, prebiotics, and phages. Front Immunol. 2018;9:2240.

Ballini A, Santacroce L, Cantore S, Bottalico L, Dipalma G, Topi S, et al. Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Controlled Pilot Study. Endocr Metab Immune Disord Drug Targets. 2019;19(3):373–81.

Y?lmaz ?, Dolar ME, Özp?nar H. Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial. Turkish J Gastroenterol Off J Turkish Soc Gastroenterol. 2019 Mar;30(3):242–53.

Kim DH, Kim S, Lee JH, Kim JH, Che X, Ma HW, et al. Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress. J Gastroenterol Hepatol. 2019;34(1):178–85.

Toscano M, De Grandi R, Miniello VL, Mattina R, Drago L. Ability of Lactobacillus kefiri LKF01 (DSM32079) to colonize the intestinal environment and modify the gut microbiota composition of healthy individuals. Dig liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver. 2017 Mar;49(3):261–7.

El Amrousy D, El Ashry H, Hodeib H, Hassan S. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial. J Clin Gastroenterol. 2021 Oct;55(9):815–20.

Palumbo VD, Romeo M, Marino Gammazza A, Carini F, Damiani P, Damiano G, et al. The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study. Biomed Pap Med Fac Univ Palacky, Olomouc, Czechoslov. 2016 Sep;160(3):372–7.

Arihiro S, Nakashima A, Matsuoka M, Suto S, Uchiyama K, Kato T, et al. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza and Upper Respiratory Infection in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2019 May;25(6):1088–95.

Lucas López R, Grande Burgos MJ, Gálvez A, Pérez Pulido R. The human gastrointestinal tract and oral microbiota in inflammatory bowel disease: a state of the science review. APMIS. 2017 Jan;125(1):3–10.

Abraham BP, Quigley EMM. Probiotics in Inflammatory Bowel Disease. Gastroenterol Clin North Am. 2017 Dec;46(4):769–82.

Andoh A, Imaeda H, Aomatsu T, Inatomi O, Bamba S, Sasaki M, et al. Comparison of the fecal microbiota profiles between ulcerative colitis and Crohn’s disease using terminal restriction fragment length polymorphism analysis. J Gastroenterol. 2011 Apr;46(4):479–86.

Marasco G, Cirota GG, Rossini B, Lungaro L, Di Biase AR, Colecchia A, et al. Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients. Nutrients. 2020 Sep;12(9).

Vanderpool C, Yan F, Polk DB. Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis. 2008 Nov;14(11):1585–96.

Meckel K, Li YC, Lim J, Kocherginsky M, Weber C, Almoghrabi A, et al. Serum 25-hydroxyvitamin D concentration is inversely associated with mucosal inflammation in patients with ulcerative colitis. Am J Clin Nutr. 2016;104(1):113–20.

Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. bmj. 2017;356.

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Published

2023-03-24

How to Cite

Rossiyah, N. . (2023). THE ROLE OF DIETARY SUPPLEMENTS IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(3), 90-95. https://doi.org/10.53555/nnmhs.v9i3.1619