NYSTAGMUS IN CHILDHOOD: A SYSTEMATIC REVIEW

Authors

  • Dea Nabila Ratu Alicia Faculty of Medicine, University of Malahayati, Indonesia

DOI:

https://doi.org/10.53555/nnmhs.v9i5.1686

Keywords:

Childhood, Eyes, Nystagmus, Ophtalmology

Abstract

Nystagmus is an involuntary rhythmic oscillation of the eyes that results in decreased visual acuity owing to the excessive motion of pictures on the retina. This is because nystagmus causes the eyes to move in a repetitive pattern. It is of the utmost importance to differentiate infantile nystagmus from acquired nystagmus. In order to accomplish this, it is necessary to take into consideration not only the time at which the nystagmus first appeared, but also the features of its waveform. Oscillations of the eyes that are involuntary, often conjugate, and frequently rhythmic are referred to as nystagmus. Infantile nystagmus syndrome (INS) is the condition that accounts for the majority of cases of nystagmus in children. Because this ailment can last a person's entire life, it is essential that they are familiar with all of the treatment choices that are at their disposal. The primary foci of this review are the underlying etiology of nystagmus, the psychosocial and functional implications of nystagmus, and the current methods of treatments, which include optical, pharmacological, surgical, and rehabilitative treatment approaches. At this time, the brain mechanisms that are responsible for INS are not completely known. The evidence is limited to mostly pre- and post-study designs, and there are few objective comparisons of treatment procedures. The treatment choices are meant to increase the foveation length or correct abnormal head positions. Individualized management of INS should be implemented. The patient and the patient's physician are the ones who should make the decision regarding which treatment will be most beneficial for the patient in question.

References

1. Papageorgiou E, McLean RJ, Gottlob I. Nystagmus in childhood. Pediatr Neonatol. 2014 Oct;55(5):341–51.

2. Kassavetis P, Kaski D, Anderson T, Hallett M. Eye Movement Disorders in Movement Disorders. Mov Disord Clin Pract [Internet]. 2022 Jan 25;n/a(n/a). Available from: https://doi.org/10.1002/mdc3.13413

3. Riordan P JA. Vaughan and Asbury’s General Ophtalmology. 19th editi. New York: McGraw Hill Education; 2018.

4. Nash DL, Diehl NN, Mohney BG. Incidence and Types of Pediatric Nystagmus. Am J Ophthalmol. 2017 Oct;182:31–4.

5. Gold DR. 16 - Eye Movement Disorders: Conjugate Gaze Abnormalities. In: Liu GT, Volpe NJ, Galetta Volpe, and Galetta’s Neuro-Ophthalmology (Third Edition) SLBT-L, editors. Elsevier; 2019. p. 549–84. Available from: https://www.sciencedirect.com/science/article/pii/B978032334044100016X

6. Self JE, Dunn MJ, Erichsen JT, Gottlob I, Griffiths HJ, Harris C, et al. Management of nystagmus in children: a review of the literature and current practice in UK specialist services. Eye (Lond). 2020 Sep;34(9):1515–34.

7. Mallipatna A, Vinekar A, Jayadev C, Dabir S, Sivakumar M, Krishnan N, et al. The use of handheld spectral domain optical coherence tomography in pediatric ophthalmology practice: Our experience of 975 infants and children. Indian J Ophthalmol. 2015 Jul;63(7):586–93.

8. He J, Lu L, Zou H, He X, Li Q, Wang W, et al. Prevalence and causes of visual impairment and rate of wearing spectacles in schools for children of migrant workers in Shanghai, China. BMC Public Health. 2014 Dec;14:1312.

9. Repka MX, Friedman DS, Katz J, Ibironke J, Giordano L, Tielsch JM. The prevalence of ocular structural disorders and nystagmus among preschool-aged children. J AAPOS Off Publ Am Assoc Pediatr Ophthalmol Strabismus. 2012 Apr;16(2):182–4.

10. Toledano H, Muhsinoglu O, Luckman J, Goldenberg-Cohen N, Michowiz S. Acquired nystagmus as the initial presenting sign of chiasmal glioma in young children. Eur J Paediatr Neurol EJPN Off J Eur Paediatr Neurol Soc. 2015 Nov;19(6):694–700.

11. Ehrt O. Infantile and acquired nystagmus in childhood. Eur J Paediatr Neurol EJPN Off J Eur Paediatr Neurol Soc. 2012 Nov;16(6):567–72.

12. Thomas MG, Crosier M, Lindsay S, Kumar A, Thomas S, Araki M, et al. The clinical and molecular genetic features of idiopathic infantile periodic alternating nystagmus. Brain. 2011 Mar;134(Pt 3):892–902.

13. Hussain N. Diagnosis, assessment and management of nystagmus in childhood. Paediatr Child Health (Oxford) [Internet]. 2016;26(1):31–6. Available from: https://www.sciencedirect.com/science/article/pii/S1751722215002188

14. Gottlob I, Proudlock FA. Aetiology of infantile nystagmus. Curr Opin Neurol. 2014 Feb;27(1):83–91.

15. Holmström G, Bondeson M-L, Eriksson U, Åkerblom H, Larsson E. ‘Congenital’ nystagmus may hide various ophthalmic diagnoses. Acta Ophthalmol [Internet]. 2014 Aug 1;92(5):412–6. Available from: https://doi.org/10.1111/aos.12250

16. Penix K, Swanson MW, DeCarlo DK. Nystagmus in pediatric patients: interventions and patient-focused perspectives. Clin Ophthalmol [Internet]. 2015 Dec 31;9:1527–36. Available from: https://www.tandfonline.com/doi/abs/10.2147/OPTH.S62786

17. Stjerna S, Sairanen V, Gröhn R, Andersson S, Metsäranta M, Lano A, et al. Visual fixation in human newborns correlates with extensive white matter networks and predicts long-term neurocognitive development. J Neurosci Off J Soc Neurosci. 2015 Mar;35(12):4824–9.

18. Decarlo DK, McGwin GJ, Bixler ML, Wallander J, Owsley C. Impact of pediatric vision impairment on daily life: results of focus groups. Optom Vis Sci Off Publ Am Acad Optom. 2012 Sep;89(9):1409–16.

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Published

2023-05-19

How to Cite

Ratu Alicia, D. N. . (2023). NYSTAGMUS IN CHILDHOOD: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(5), 69-73. https://doi.org/10.53555/nnmhs.v9i5.1686