A SYSTEMATIC REVIEW ON DROPOUT OF INFERTILITY TREATMENTS AND RELATED FACTORS

Authors

  • Dea Nabila Ratu Alicia Faculty of Medicine, University of Malahayati, Indonesia

DOI:

https://doi.org/10.53555/nnmhs.v9i5.1687

Keywords:

Drop Out, Infertility, In Vitro Fertilization (IVF), Ovulation, Pregnancy

Abstract

Infertility occurs when a couple has been unable to produce a child for a period of at least one year while engaging in regular sexual activity and not using any kind of birth control. In addition, the pair must not have used any form of contraception during that time period. Fecundity is defined as a woman's ability to carry a pregnancy to full term without experiencing complications. Studies conducted on populations indicate that the probability of a woman becoming pregnant at any given month ranges between 20 and 25 percent overall. It is difficult to compare dropout rates across different facilities and nations due to factors such as the expense of infertility treatments, the regulations that control payment, and the accessibility of these therapies. The overwhelming majority of fertility specialists are obsessed with the outcomes of therapy and the success rates of their patients, but they frequently ignore or forget about the "invisible" individuals who withdraw from treatment. There is a lack of clarity regarding the causes and factors that lead individuals to quit focusing on their relationships. Many married couples find that they are better off financially if they choose to forego having any more children. During the period of mourning that is linked with an inability to produce children, undergoing at least one cycle of in vitro fertilization (IVF) may be performed as a "ritual." Several studies have found a correlation between dropout and a number of factors, some of which are as follows: emotional factors, communication issues, delaying treatment, physical and psychological burden, personal problems, refusal to accept treatment, problems related to the infertility organization and clinics, marital issues, age of women, number of previous births, previous unsuccessful treatments, poor treatment prognosis, child adoption, spontaneous pregnancy, and lack of insurance coverage are among the factors that have been found.

References

1. ASRM. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2013;99(1):63.

2. Fainberg J, Kashanian JA. Recent advances in understanding and managing male infertility. F1000Research. 2019;8.

3. Cunningham FG; et al, Cunningham FG; Leveno KJ; Bloom SL; et al, F. Gary Cunningham, Kenneth J. Leveno, Steven L. Bloom, Catherine Y. Spong, Jodi S. Dashe BLH. Williams Obstetri. 25th ed. New York: The McGraw-Hill Companies; 2020.

4. Simionescu G, Doroftei B, Maftei R, et al. The complex relationship between infertility and psychological distress (Review). Exp Ther Med. 2021;306(3):198–202.

5. Datta AK, Campbell S, Felix N, Nargund G. Accumulation of embryos over 3 natural modified IVF (ICSI) cycles followed by transfer to improve the outcome of poor responders. Facts, views Vis ObGyn. 2019 Mar;11(1):77–84.

6. Ghorbani M, Hoseini FS, Yunesian M, Keramat A. Dropout of Infertility Treatments Among Iranian Infertile Couples: A Cohort Study. 2021;

7. Ghorbani M, Hoseini FS, Salehin S, Talebi SS, Keramat A. A supportive randomized clinical trial on Iranian infertile women with the history of infertility treatments dropout following unsuccessful ART cycle/s: A study protocol. Heliyon. 2023;9(3).

8. Dueholm Hjorth IM, Kristensen SG, Dueholm M, Humaidan P. Reproductive outcomes after in vitro fertilization treatment in a cohort of Danish women transplanted with cryopreserved ovarian tissue. Fertil Steril. 2020 Aug;114(2):379–87.

9. Domar AD, Rooney KL, Dodge LE. Determining the reasons why insured women drop out of IVF treatment after one unsuccessful cycle. Fertil Steril. 2019;112(3):e398.

10. Vaiarelli A, Cimadomo D, Gennarelli G, Guido M, Alviggi C, Conforti A, et al. Second stimulation in the same ovarian cycle: an option to fully-personalize the treatment in poor prognosis patients undergoing PGT-A. J Assist Reprod Genet. 2022;39(3):663–73.

11. Ghorbani M, Hosseini FS, Yunesian M, Keramat A. Dropout of infertility treatments and related factors among infertile couples. Reprod Health [Internet]. 2020;17(1):192. Available from: https://doi.org/10.1186/s12978-020-01048-w

12. Arhin SM, Mensah KB, Agbeno EK, Azize DA, Henneh IT, Agyemang E, et al. Pharmacotherapy of infertility in Ghana: Why do infertile patients discontinue their fertility treatment? PLoS One [Internet]. 2022 Oct 17;17(10):e0274635. Available from: https://doi.org/10.1371/journal.pone.0274635

13. Miller LM, Wallace G, Birdsall MA, Hammond ER, Peek JC. Dropout rate and cumulative birth outcomes in couples undergoing in vitro fertilization within a funded and actively managed system of care in New Zealand. Fertil Steril [Internet]. 2021;116(1):114–22. Available from: https://www.sciencedirect.com/science/article/pii/S0015028221000625

14. ASRM. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012;98:591–8.

15. Kella AA; Despande SB. Pulmonary surfactants and their role in pathophysiologi of Lung Disorders. Indian J. 2013;5–22.

16. Van den Broeck U, Holvoet L, Enzlin P, Bakelants E, Demyttenaere K, D’Hooghe T. Reasons for Dropout in Infertility Treatment. Gynecol Obstet Invest [Internet]. 2009;68(1):58–64. Available from: https://www.karger.com/DOI/10.1159/000214839

17. Domar AD. Impact of psychological factors on dropout rates in insured infertility patients. Fertil Steril. 2004;81(2):271–3.

18. Eugster A, Vingerhoets AJJM. Psychological aspects of in vitro fertilization: a review. Soc Sci Med. 1999;48(5):575–89.

19. Domar AD, Smith K, Conboy L, Iannone M, Alper M. A prospective investigation into the reasons why insured United States patients drop out of in vitro fertilization treatment. Fertil Steril. 2010;94(4):1457–9.

20. Deshpande PS, Gupta AS. Causes and prevalence of factors causing infertility in a public health facility. J Hum Reprod Sci. 2019;12(4):287.

21. Dhont N, Luchters S, Ombelet W, Vyankandondera J, Gasarabwe A, Van de Wijgert J, et al. Gender differences and factors associated with treatment-seeking behaviour for infertility in Rwanda. Hum Reprod. 2010;25(8):2024–30.

22. Gameiro S, Verhaak CM, Kremer JAM, Boivin J. Why we should talk about compliance with assisted reproductive technologies (ART): a systematic review and meta-analysis of ART compliance rates. Hum Reprod Update. 2013;19(2):124–35.

23. Troude P, Guibert J, Bouyer J, de La Rochebrochard E, Group D. Medical factors associated with early IVF discontinuation. Reprod Biomed Online. 2014;28(3):321–9.

Downloads

Published

2023-05-19

How to Cite

Ratu Alicia, D. N. (2023). A SYSTEMATIC REVIEW ON DROPOUT OF INFERTILITY TREATMENTS AND RELATED FACTORS. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(5), 74-80. https://doi.org/10.53555/nnmhs.v9i5.1687