GASTROINTESTINAL SYMPTOMS ARE ASSOCIATED WITH SEVERITY OF CORONAVIRUS DISEASE 2019: A SYSTEMATIC REVIEW

Authors

  • Lie Milka Ardena Lianto Faculty of Medicine, Maranatha Christian University, Indonesia

DOI:

https://doi.org/10.53555/nnmhs.v9i6.1732

Keywords:

Gastrointestinal symptoms, Gastrointestinal manifestation, COVID-19 severity, Mortality

Abstract

Background:

Aim: This study aims to summarize and evaluate the association between GI symptoms in COVID-19 and disease severity.

Methods: A systematic search strategy was conducted across several electronic reference databases (PubMed, Cochrane Library, Google Scholar) and included articles published between 2019–2023. Duplicate publications, review articles, and incomplete articles were excluded.

Results: Database searches identified a total of 17632 articles. Of these, 100 articles passed the screening process, resulting in 15 articles for full-text assessment. Among them, 6 articles did not evaluate the outcome of interest. Hence, we found 9 appropriate studies included.

Conclusion: Current findings are insufficient to establish a association between GI symptoms and disease severity in COVID-19 patients.

References

Mortaz E, Tabarsi P, Varahram M, Folkerts G, Adcock IM. The Immune Response and Immunopathology of COVID-19. Front Immunol. 2020;11(August):1–9.

World Health Organization. WHO Coronavirus (COVID-19) [Internet]. 2023 [cited 2023 Jun 14]. Available from: https://covid19.who.int/

Hayashi Y, Wagatsuma K, Nojima M, Yamakawa T, Ichimiya T, Yokoyama Y, et al. The characteristics of gastrointestinal symptoms in patients with severe COVID-19: a systematic review and meta-analysis. J Gastroenterol [Internet]. 2021;56(5):409–20. Available from: https://doi.org/10.1007/s00535-021-01778-z

Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention. JAMA - J Am Med Assoc. 2020;323(13):1239–42.

Parasa S, Desai M, Thoguluva Chandrasekar V, Patel HK, Kennedy KF, Roesch T, et al. Prevalence of Gastrointestinal Symptoms and Fecal Viral Shedding in Patients with Coronavirus Disease 2019: A Systematic Review and Meta-analysis. Vol. 3, JAMA Network Open. 2020.

ultan S, Altayar O, Siddique SM, Davitkov P, Feuerstein JD, Lim JK, et al. AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19. Gastroenterology. 2020;159(1).

Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for Gastrointestinal Infection of SARS-CoV-2. Gastroenterology. 2020;158(6).

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA - J Am Med Assoc. 2020;323(11):1061–9.

Zhang G, Hu C, Luo L, Fang F, Chen Y, Li J, et al. Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China. J Clin Virol [Internet]. 2020;127(April):104364. Available from: https://doi.org/10.1016/j.jcv.2020.104364

Zhang J jin, Dong X, Cao Y yuan, Yuan Y dong, Yang Y bin, Yan Y qin, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy Eur J Allergy Clin Immunol. 2020;75(7):1730–41.

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683–90.

Chen Q, Zheng Z, Zhang C, Zhang X, Wu H, Wang J, et al. Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection [Internet]. 2020;48(4):543–51. Available from: https://doi.org/10.1007/s15010-020-01432-5

He R, Lu Z, Zhang L, Fan T, Xiong R, Shen X, et al. The clinical course and its correlated immune status in COVID-19 pneumonia. J Clin Virol [Internet]. 2020;127(April):104361. Available from: https://doi.org/10.1016/j.jcv.2020.104361

Zhang R, Ouyang H, Fu L, Wang S, Han J, Huang K, et al. CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city. Eur Radiol. 2020;30(8):4417–26.

Wan Y, Li J, Shen L, Zou Y, Hou L, Zhu L, et al. Enteric involvement in hospitalised patients with COVID-19 outside Wuhan. Lancet Gastroenterol Hepatol [Internet]. 2020;5(6):534–5. Available from: http://dx.doi.org/10.1016/S2468-1253(20)30118-7

Nobel YR, Phipps M, Zucker J, Lebwohl B, Wang TC, Sobieszczyk ME, et al. Gastrointestinal Symptoms and Coronavirus Disease 2019: A Case-Control Study From the United States. Gastroenterology [Internet]. 2020;159(1):373-375.e2. Available from: https://doi.org/10.1053/j.gastro.2020.04.017

Ghweil AA, Hassan MH, Khodeary A, Mohamed AO, Mohammed HM, Abdelazez AA, et al. Characteristics, outcomes and indicators of severity for covid-19 among sample of esna quarantine hospital’s patients, egypt: A retrospective study. Infect Drug Resist. 2020;13:2375–83.

Huang J-T. Chronological Changes of Viral Shedding in Adult Inpatients with COVID- 19 in Wuhan, China. Journals Gerontol Ser A Biol Sci Med Sci. 2018;0813(April):1–11.

Yang L, Liu J, Zhang R, Li M, Li Z, Zhou X, et al. Epidemiological and clinical features of 200 hospitalized patients with corona virus disease 2019 outside Wuhan, China: A descriptive study. J Clin Virol. 2020;129.

Zhang J, Wang X, Jia X, Li J, Hu K, Chen G, et al. Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China. Clin Microbiol Infect. 2020;26(6):767–72.

Zhong ZF, Huang J, Yang X, Peng JL, Zhang XY, Hu Y, et al. Epidemiological and clinical characteristics of COVID-19 patients in Hengyang, Hunan Province, China. World J Clin Cases. 2020;8(12):2554–65.

Hossain B, Ahmad S, Saleem A, Oranu A. Prevalence and Impact of Gastrointestinal Manifestations in COVID-19 Patients: A Systematic Review. J Community Hosp Intern Med Perspect. 2023;13:39–54.

FANG D, MA J, GUAN J, WANG M, SONG Y, TIAN D, et al. Manifestations of Digestive system in hospitalized patients with novel coronavirus pneumonia in Wuhan, China: a single-center, descriptive study. Chinese J Dig. 2020;40(0 PG-5–5).

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708–20.

Liu J, Cui M, Yang T, Yao P. Correlation between gastrointestinal symptoms and disease severity in patients with COVID-19: A systematic review and meta-analysis. BMJ Open Gastroenterol. 2020;7(1):1–5.

Zeng W, Qi K, Ye M, Zheng L, Liu X, Hu S, et al. Gastrointestinal symptoms are associated with severity of coronavirus disease 2019: A systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2022;34(2):168–76.

Menon T, Sharma R, Earthineni G, Iftikhar H, Sondhi M, Shams S, et al. Association of Gastrointestinal System With Severity and Mortality of COVID-19: A Systematic Review and Meta-Analysis. Cureus. 2021;13(2).

Xue W, Honda M, Hibi T. Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients. World J Gastroenterol. 2023;29(15):2283–93.

Liang W, Feng Z, Rao S, Xiao C, Xue X, Lin Z, et al. Diarrhoea may be underestimated: A missing link in 2019 novel coronavirus. Vol. 69, Gut. 2020.

Downloads

Published

2023-06-22

How to Cite

Ardena Lianto, L. M. . (2023). GASTROINTESTINAL SYMPTOMS ARE ASSOCIATED WITH SEVERITY OF CORONAVIRUS DISEASE 2019: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(6), 49-53. https://doi.org/10.53555/nnmhs.v9i6.1732