LACTIC ACIDOSIS IN A PATIENT WITH TYPE 2 DIABETES MELLITUS: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.53555/nnmhs.v9i7.1770Keywords:
Diabetes mellitus, Lactic acidosis, MetforminAbstract
Background: Lactic acidosis occurs when lactate synthesis exceeds metabolism. Multiple causes of lactic acidosis may coexist in a patient. Attending Rounds exemplifies the theme. This example shows how metformin can complicate type 2 diabetes-related lactic acidosis. Lactic acidosis treatment is controversial, because it must address the cause.
Aim: This article examines the link between lactic acidosis in a patient with type 2 diabetes mellitus.
Methods: This study showed that it met all of the requirements by looking at the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 guidelines. So, the experts could make sure that the study was as current as possible. The search method used a number of electronic reference databases, such as Pubmed and SagePub, to look for papers that were published between 2000 and 2023. We didn't look at review papers, articles that had already been published, or articles that were only half done.
Result: In the PubMed database, the results of our search brought up 77 articles, whereas the results of our search on SagePub brought up 56 articles. The results of the search conducted for the last year of 2013 yielded a total of 17 articles for PubMed and 6 articles for SagePub. In the end, we compiled a total of 18 papers, 13 of which came from PubMed and five of which came from SagePub. We included five research that met the criteria.
Conclusion: Studies consistently show that blood lactate levels in patients taking metformin are increased, but are not significantly associated with the risk of developing lactic acidosis.
References
1. International Diabetes Federation. Diabetes. Brussels: IDF; 2017.
2. Evans K. Diabetic ketoacidosis: update on management. Clin Med. 2019 Sep;19(5):396–8.
3. Association AD. 15. Diabetes Care in the Hospital: Standards of Medical Care in Diabetes—2019. Diabetes Care [Internet]. 2018 Dec 7;42(Supplement_1):S173–81. Available from: https://doi.org/10.2337/dc19-S015
4. American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2016;62–9.
5. Soelistijo SA, Lindarto D, Decroli E, et al. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia. Jakarta: PB Perkeni; 2021.
6. Patoulias D, Papadopoulos C, Stavropoulos K, et al. Prognostic value of arterial stiffness measurements in cardiovascular disease, diabetes, and its complications: The potential role of sodium-glucose co-transporter-2 inhibitors. J Clin Hypertens. 2020;22(4):562–71.
7. Kraut JA, Madias NE. Lactic acidosis. N Engl J Med. 2014 Dec;371(24):2309–19.
8. Chen W, Levy DS, Abramowitz MK. Acid Base Balance and Progression of Kidney Disease. Semin Nephrol. 2019 Jul;39(4):406–17.
9. Kennelly PJ, Rodwell VW. Harper’s: Illustrated Biochemistry. New York: McGraw-Hill Education; 2016.
10. Weisberg LS. Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus. Clin J Am Soc Nephrol. 2015 Aug;10(8):1476–83.
11. Aharaz A, Pottegård A, Henriksen DP, Hallas J, Beck-Nielsen H, Lassen AT. Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study. PLoS One. 2018;13(5):e0196122.
12. Lepelley M, Giai J, Yahiaoui N, Chanoine S, Villier C. Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University. J Diabetes Res. 2016;2016:3545914.
13. Eppenga WL, Lalmohamed A, Geerts AF, Derijks HJ, Wensing M, Egberts A, et al. Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. Diabetes Care. 2014 Aug;37(8):2218–24.
14. Guelho D, Paiva I, Carrilho F. Relation between metformin treatment and the development of hyperlactacidemia at the emergency room. Acta Med Port. 2014;27(2):196–203.
15. Fauci AS, Jameson JL, Kasper D, et al. Harrison’s Principles of Internal Medicine 19th Edition. New York: McGraw-Hill Education; 2018.
16. Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: an update. Ann Intern Med. 2002;137(1):25–33.
17. Lalau J-D, Arnouts P, Sharif A, De Broe ME. Metformin and other antidiabetic agents in renal failure patients. Kidney Int. 2015;87(2):308–22.
18. Scale T, Harvey JN. Diabetes, metformin and lactic acidosis. Clin Endocrinol (Oxf). 2011 Feb;74(2):191–6.
19. Madiraju AK, Erion DM, Rahimi Y, Zhang X-M, Braddock DT, Albright RA, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014 Jun;510(7506):542–6.
20. Vecchio S, Giampreti A, Petrolini VM, Lonati D, Protti A, Papa P, et al. Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. Clin Toxicol. 2014;52(2):129–35.
21. Lee EY, Hwang S, Lee YH, Lee SH, Lee YM, Kang HP, et al. Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. Yonsei Med J. 2017 Mar;58(2):312–8.
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