EFFICACY OF INTENSE PULSED LIGHT THERAPY ON SIGNS AND SYMPTOMS OF DRY EYE DISEASE : A SYSTEMATIC REVIEW

Authors

  • Yovita Faculty of Medicine, Maranatha Christian University, Indonesia

DOI:

https://doi.org/10.53555/nnmhs.v9i8.1821

Keywords:

Dry eye disease, Meibomian gland dysfunction, Pulsed light therapy

Abstract

Introduction: Dry eye disease (DED) is a multifactorial disorder of the ocular surface characterized by disruption of tear film homeostasis, instability of the tear film, and inflammation of the ocular surface. Although the precise mechanism of action is still inadequately understood, numerous studies have demonstrated that IPL has the potential to alleviate both the signs and symptoms of dry eye.

The aim: This article showed efficacy of intense pulsed light therapy on signs and symptoms of dry eye disease.

Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.

Result: In the PubMed database, the results of our search brought up 112 articles, whereas the results of our search on SagePub brought up 109 articles. The results of the search conducted for the last year of 2013 yielded a total 25 articles for PubMed and 19 articles for SagePub. In the end, we compiled a total of 23 papers, 14 of which came from PubMed and nine of which came from SagePub. We included sixresearch that met the criteria.

Conclusion: Existing research indicates that Intense Pulsed Light (IPL) therapy has the potential to alleviate the symptoms and manifestations of Dry Eye Disease (DED). Previous research did not demonstrate any significant adverse effects.

References

. Nelson JD, Craig JP, Akpek EK, Azar DT, Belmonte C, Bron AJ, et al. TFOS DEWS II Introduction. Ocul Surf. 2017 Jul;15(3):269–75.

. Shimazaki J. Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions. Invest Ophthalmol Vis Sci. 2018 Nov;59(14):DES7–12.

. Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, et al. TFOS DEWS II Epidemiology Report. Ocul Surf. 2017 Jul;15(3):334–65.

. Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, et al. TFOS DEWS II pathophysiology report. Ocul Surf. 2017 Jul;15(3):438–510.

. Nelson JD, Shimazaki J, Benitez-del-Castillo JM, Craig JP, McCulley JP, Den S, et al. The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee. Invest Ophthalmol Vis Sci. 2011 Mar;52(4):1930–7.

. Kaiserman I, Rabina G, Mimouni M, Sadi Optom NB, Duvdevan N, Levartovsky S, et al. The effect of therapeutic meibomian glands expression on evaporative dry eye: a prospective randomized controlled trial. Curr Eye Res. 2021;46(2):195–201.

. Viso E, Millán AC, Rodríguez-Ares MT. Rosacea-associated meibomian gland dysfunction—an epidemiological perspective. Eur Ophthalmic Rev. 2014;8(1):13–6.

. Wat H, Wu DC, Rao J, Goldman MP. Application of intense pulsed light in the treatment of dermatologic disease: a systematic review. Dermatologic Surg Off Publ Am Soc Dermatologic Surg [et al]. 2014 Apr;40(4):359–77.

. Toyos R, Desai NR, Toyos M, Dell SJ. Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study. PLoS One. 2022;17(6):e0270268.

. Jones L, Downie LE, Korb D, Benitez-del-Castillo JM, Dana R, Deng SX, et al. TFOS DEWS II management and therapy report. Ocul Surf. 2017;15(3):575–628.

. Yan S, Wu Y. Efficacy and safety of Intense pulsed light therapy for dry eye caused by meibomian gland dysfunction: a randomised trial. Ann Palliat Med. 2021 Jul;10(7):7857–65.

. Yan X, Hong J, Jin X, Chen W, Rong B, Feng Y, et al. The Efficacy of Intense Pulsed Light Combined With Meibomian Gland Expression for the Treatment of Dry Eye Disease Due to Meibomian Gland Dysfunction: A Multicenter, Randomized Controlled Trial. Eye Contact Lens. 2021 Jan;47(1):45–53.

. Toyos R, Toyos M, Willcox J, Mulliniks H, Hoover J. Evaluation of the Safety and Efficacy of Intense Pulsed Light Treatment with Meibomian Gland Expression of the Upper Eyelids for Dry Eye Disease. Photobiomodulation, photomedicine, laser Surg. 2019 Sep;37(9):527–31.

. Toyos R, McGill W, Briscoe D. Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study. Photomed Laser Surg. 2015 Jan;33(1):41–6.

. Craig JP, Chen Y-H, Turnbull PRK. Prospective trial of intense pulsed light for the treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2015 Feb;56(3):1965–70.

. Liu R, Rong B, Tu P, Tang Y, Song W, Toyos R, et al. Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction. Am J Ophthalmol. 2017 Nov;183:81–90.

. Calderhead RG. The photobiological basics behind light-emitting diode (LED) phototherapy. Laser Ther. 2007;16(2):97–108.

. Kim J, Lee J, Choi H. Intense pulsed light attenuates UV-induced hyperimmune response and pigmentation in human skin cells. Int J Mol Sci. 2021;22(6):3173.

. Prieto VG, Diwan AH, Shea CR, Zhang P, Sadick NS. Effects of intense pulsed light and the 1,064 nm Nd:YAG laser on sun-damaged human skin: histologic and immunohistochemical analysis. Dermatologic Surg Off Publ Am Soc Dermatologic Surg [et al]. 2005 May;31(5):522–5.

. Arita R, Fukuoka S, Morishige N. Therapeutic efficacy of intense pulsed light in patients with refractory meibomian gland dysfunction. Ocul Surf. 2019 Jan;17(1):104–10.

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Published

2023-08-21

How to Cite

Yovita. (2023). EFFICACY OF INTENSE PULSED LIGHT THERAPY ON SIGNS AND SYMPTOMS OF DRY EYE DISEASE : A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(8), 196-201. https://doi.org/10.53555/nnmhs.v9i8.1821