ACNE AND INSULIN RESISTANCE: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.53555/yxrefa30Keywords:
Acne, Glucose, Inflammation, Insulin resistanceAbstract
Acne is a skin disorder that is characterized by persistent inflammation and involves the folliculopilosebaceous unit. It has an impact on a sizeable portion of the general population. Acne affects a disproportionate number of females and teenagers, especially those between the ages of 15 and 24, who are most susceptible to the condition. In recent times, there has been seen to be a growing interest in the possible connection between acne and insulin resistance (IR). This attention has been seen, and it is appreciated. It would appear that IR has a strong connection to acne, which is a persistent skin condition that can lead to inflammation. Research has been conducted on a wide variety of etiopathological factors that have been associated with the progression of IR. It would appear that obesity is one of the most common. Additionally, it would appear that factors such as chronic inflammation, hypertriglyceridemia, low HDL serum concentration, mitochondrial dysfunction, gut microbiota, and the excess activity of antagonistic hormones such as cortisol, glucagon, and thyroid hormones all play a significant role in the development of this condition. We identified a linkage between insulin resistance and severe acne vulgaris, which was reported to have a positive link with insulin resistance. On the basis of these findings, it is a legitimate assumption to hypothesize that medications that are now utilized for the treatment of insulin resistance would also be helpful for the treatment of severe acne vulgaris.
References
Napolitano M, Megna M, Monfrecola G. Insulin resistance and skin diseases. ScientificWorldJournal. 2015;2015:479354.
Bolognia J, Jorrizo J, Schaffer J. Dermatology. 3 ed. New York: Elsevier; 2013.
Wolff K, Johnson R, Saavedra A. Fitzpatrick Color Atlas and Synopsis of Clinical Dermatology. New York: McGraw-Hill Education; 2012.
Melnik BC. Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle. Clin Dermatol. 2018;36(1):29–40.
Mwanthi M, Zaenglein AL. Update in the management of acne in adolescence. Curr Opin Pediatr. Agustus 2018;30(4):492–8.
Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. Juli 2000;85(7):2402–10.
Gupta A, Sharma YK, Dash KN, Chaudhari ND, Jethani S. Quality of life in acne vulgaris: Relationship to clinical severity and demographic data. Indian J Dermatol Venereol Leprol. 2016;82(3):292–7.
Auffret N, Claudel J-P, Leccia M-T, Poli F, Farhi D, Dréno B. AFAST - Adult Female Acne Scoring Tool: an easy-to-use tool for scoring acne in adult females. J Eur Acad Dermatol Venereol. Mei 2016;30(5):824–8.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.