ASSOCIATION BETWEEN VITAMIN D AND GLAUCOMA: A SYSTEMATIC REVIEW

Authors

  • Alyssa Claudia Valerie Gunawan Faculty of Medicine, Widya Mandala Catholic University, Surabaya, Indonesia
  • Aquirina Caesari Putri Ophthalmologist, Mata Masyarakat Jawa Timur Hospital, Surabaya, Indonesia
  • Anggia Dwi Stephanie Tandipayuk Faculty of Medicine, Widya Mandala Catholic University, Surabaya, Indonesia
  • Fulgensius Atin Faculty of Medicine, Widya Mandala Catholic University, Surabaya, Indonesia

DOI:

https://doi.org/10.61841/wh1skq85

Keywords:

Glaucoma, Serum 25-hydroxyvitamin D, Vitamin D

Abstract

Background: Glaucoma is a chronic progressive optic neuropathy that causes irreversible damage. Therefore, early diagnosis and appropriate treatment to control various risk factors associated with glaucoma are important. Risk factors associated with the development of glaucoma have been reported by many researchers and include both ocular and non-ocular (systemic) factors such as myopia, central corneal thickness, disc hemorrhage, and genetic factors.

The aim: This study aims to show association vitamin D to glaucoma.  

Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.

Result: In the PubMed database, the results of our search brought up 89 articles, whereas the results of our search on SagePub brought up 98 articles. The results of the search conducted for the last year of 2013 yielded a total 13 articles for PubMed and 26 articles for SagePub. The result from title screening, a total 2 articles for PubMed and 18 articles for SagePub. In the end, we compiled a total of 10 papers. We included five research that met the criteria.

Conclusion: Decreased serum 25-OHD concentration was associated with the presence but not the severity of POAG. It was suggested that Vitamin D deficiency should be considered a potential risk factor for the development of open-angle glaucoma.

References

Basamat A. Unique phenotypic–genotypic correlation in Saudi patients with ALMS1 mutations. Sjo. 2022;(8.5.2017):2003–5.

Yoo TK, Oh E, Hong S. Is vitamin D status associated with open-angle glaucoma A cross-sectional study from South Korea. Public Health Nutr. 2014;17(4):833–43.

Ramdas WD, Schouten JSAG, Webers CAB. The effect of vitamins on glaucoma: A systematic review and meta-analysis. Nutrients. 2018;10(3).

Morelli-Batters A, Lamont HC, Elghobashy M, Masood I, Hill LJ. The role of Vitamin D3 in ocular fibrosis and its therapeutic potential for the glaucomatous trabecular meshwork. Front Ophthalmol. 2022;2(August):1–8.

Kim HT, Kim JM, Kim JH, Lee MY, Won YS, Lee JY, et al. The Relationship between Vitamin D and Glaucoma: A Kangbuk Samsung Health Study. Korean J Ophthalmol. 2016;30(6):426–33.

Lee T, Jammal AA, Medeiros FA. Association between Serum Vitamin D Level and Rates of Structural and Functional Glaucomatous Progression. J Glaucoma. 2022;31(7):614–21.

Abass I, Saleh A, Badi A, Mohammad B, Hamied F, Al-Aubaidy H. Correlation of serum 1,25-dihydroxycholecalciferol with the incidence of primary open-angle glaucoma: A cross-sectional study on patients with chronic illnesses. Saudi J Ophthalmol [Internet]. 2023;37(3):247. Available from: https://journals.lww.com/10.4103/sjopt.sjopt_169_22

Lee JH, Kwon YJ, Lee HS, Han JH, Joung B, Kim SJ. Inverse Relationship between Serum 25-Hydroxyvitamin D and Elevated Intraocular Pressure. Nutrients. 2023;15(2).

Lv Y, Yao Q, Ma W, Liu H, Ji J, Li X. Associations of Vitamin D deficiency and Vitamin D receptor (Cdx-2, Fok I, Bsm i and Taq I) polymorphisms with the risk of primary open-angle glaucoma. BMC Ophthalmol [Internet]. 2016;16(1):1–7. Available from: http://dx.doi.org/10.1186/s12886-016-0289-y

Chan HN, Zhang XJ, Ling XT, Bui CHT, Wang YM, Ip P, et al. Vitamin D and Ocular Diseases: A Systematic Review. Int J Mol Sci. 2022;23(8):1–58.

Daldal H, Gokmen Salici A. Ocular Findings Among Patients With Vitamin D Deficiency. Cureus. 2021;13(5).

Cho Y, Yun SP, Yoo WS, Kim RB, Cho MC, Kim SJ. Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma. Sci Rep [Internet]. 2021;11(1):1–8. Available from: https://doi.org/10.1038/s41598-021-98342-9

Downloads

Published

2023-12-31

How to Cite

Valerie Gunawan, A. C. ., Caesari Putri, A. ., Stephanie Tandipayuk, A. D. ., & Atin, F. . (2023). ASSOCIATION BETWEEN VITAMIN D AND GLAUCOMA: A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 9(12), 217-223. https://doi.org/10.61841/wh1skq85