ENDOTHELIN-1 ROLE IN HUMAN EYE: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.61841/hzdyb054Keywords:
Endothelin-1, vasoactive, eyeAbstract
Background: Endothelin-1 (ET-1) is a potent vasoactive factor implicated in development of diabetic retinopathy, which is commonly associated with retinal edema and hyperglycemia. Although the vasomotor activity of venules contributes to the regulation of tissue fluid homeostasis, responses of human retinal venules to ET-1 under euglycemia and hyperglycemia remain unknown and the ET-1 receptor subtype corresponding to vasomotor function has not been determined.
The aim: This study aims to show endothelin-1 role in human eye.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database the results of our search brought up 44 articles, whereas the results of our search on SagePub brought up 95 articles. The results of the search conducted for the last year of 2013 yielded a total 15 articles for PubMed and 42 articles for SagePub. The result from title screening, a total 4 articles for PubMed and 12 articles for SagePub. In the end, we compiled a total of 8 papers. We included five research that met the criteria.
Conclusion: ET-1 (vasoconstrictor, mitogenic, pro-oxidative, and proinflammatory) is one of the most potent vasoconstrictors in the body and its action has a dual effect: on the one hand, it acts on receptors of ECs and pericytes; on the other hand, it has a mitogenic effect on VSMCs.
References
Marola OJ, Howell GR, Libby RT. Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death. Cell Death Discov. 2022;8(1):1–10.
Chen YL, Rosa RH, Kuo L, Hein TW. Hyperglycemia augments endothelin-1–induced constriction of human retinal venules. Transl Vis Sci Technol. 2020;9(9):1–10.
Chen YL, Ren Y, Xu W, Rosa RH, Kuo L, Hein TW. Constriction of retinal venules to endothelin-1: Obligatory roles of ET A receptors, extracellular calcium entry, and Rho kinase. Investig Ophthalmol Vis Sci. 2018;59(12):5167–75.
Khuu LA, Tayyari F, Sivak JM, Flanagan JG, Singer S, Brent MH, et al. Aqueous humor endothelin-1 and total retinal blood flow in patients with non-proliferative diabetic retinopathy. Eye [Internet]. 2017;31(10):1443–50. Available from: http://dx.doi.org/10.1038/eye.2017.74
Lommatzsch C, Rothaus K, Schopmeyer L, Feldmann M, Bauer D, Grisanti S, et al. Elevated endothelin-1 levels as risk factor for an impaired ocular blood flow measured by OCT-A in glaucoma. Sci Rep [Internet]. 2022;12(1):1–12. Available from: https://doi.org/10.1038/s41598-022-15401-5
Kang HM, Hasanuzzaman M, Kim SW, Koh HJ, Lee SC. Significant elevation of aqueous endothelin-1 in central retinal vein occlusion. PLoS One [Internet]. 2021;16(6 June):1–12. Available from: http://dx.doi.org/10.1371/journal.pone.0252530
Kang HM, Hasanuzzaman M, Kim SW, Koh HJ, Lee SC. Elevated aqueous endothelin-1 concentrations in advanced diabetic retinopathy. PLoS One [Internet]. 2022;17(5 May):1–12. Available from: http://dx.doi.org/10.1371/journal.pone.0268353
Sorrentino FS, Bonifazzi C, Perri P. The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa. J Ophthalmol. 2015;2015.
Sorrentino FS, Matteini S, Bonifazzi C, Sebastiani A, Parmeggiani F. Diabetic retinopathy and endothelin system: Microangiopathy versus endothelial dysfunction. Eye [Internet]. 2018;32(7):1157–63. Available from: http://dx.doi.org/10.1038/s41433-018-0032-4
Chaphalkar RM, Stankowska DL, He S, Kodati B, Phillips N, Prah J, et al. Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells. Sci Rep [Internet]. 2020;10(1):1–14. Available from: http://dx.doi.org/10.1038/s41598-020-60558-6
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
