ANTIBIOTICS FOR TREATMENT OF ACUTE APPENDICITIS : A SYSTEMATIC REVIEW

Authors

  • Windy Rhomadani Putra Faculty of Medicine, Sultan Agung Islamic University, Indonesia
  • Atika Rochmahyanti General Practitioner, Cimacan General Hospital, Cianjur, Indonesia

DOI:

https://doi.org/10.61841/505y3779

Keywords:

Antibiotics, Acute Appendicitis, Efficacy

Abstract

Background: Appendicitis is one of the most common causes of acute abdominal discomfort in adults and children, with a lifetime risk of 8.6 in males and 6.7 in females.

Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.

Result: In the PubMed database, the results of our search brought up 259 articles, whereas the results of our search on SagePub brought up 148 articles. The results of the search conducted for the last year of 2014 yielded a total 15 articles for PubMed and 11 articles for SagePub. In the end, we compiled a total of  6 papers, 4 of which came from PubMed and 2 of which came from SagePub. We included six research that met the criteria.

Conclusion: In summary, when selecting antimicrobial medications to treat acute appendicitis, patients who are especially worried about recurrence of appendicitis should use caution. Patients who failed antibiotic treatment first and underwent surgery later could not possibly result in a higher risk of postoperative complications and the acute appendicitis does not develop to complicated appendicitis in this course, which made antibiotic treatment appealing for patients with acuteacute appendicitis who do not want surgery without having to worry about complications or complicating the original illness.

References

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Gignoux B, Blanchet MC, Lanz T, Vulliez A, Saffarini M, Bothorel H, et al. Should ambulatory appendectomy become the standard treatment for acute appendicitis World Journal of Emergency Surgery. 2018 Jun 28;13(1).

Salminen P, Paajanen H, Rautio T, Nordstrom P, Aarnio M, Rantanen T, et al. Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA. 2015;313(23):2340–8.

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Sajjad MN, Naumeri F, Hina S. Non-operative treatment versus appendectomy for acute uncomplicated appendicitis: A randomized controlled trial. Pak J Med Sci. 2021 Sep 1;37(5):1276–81.

Flum DR, Davidson GH, Monsell SE, Shapiro NI. A Randomized Clinical Trial Evaluating the Efficacy and Quality of Life of Antibiotic-only Treatment of Acute Uncomplicated Appendicitis: Results of the COMMA Trial. N Engl J Med. 2020;383(20):1907–19.

Ferris M, Quan S, Kaplan BS, Molodecky N, Ball CG. The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies. Ann Surg. 2017;266(2):237–41.

Xu H, Yang S, Xing J, Wang Y, Sun W, Rong L, et al. Comparison of the efficacy and safety of antibiotic treatment and appendectomy for acute uncomplicated appendicitis: a systematic review and meta-analysis. BMC Surg. 2023 Dec 1;23(1).

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Published

2024-01-13

How to Cite

Rhomadani Putra, W. ., & Rochmahyanti, A. . (2024). ANTIBIOTICS FOR TREATMENT OF ACUTE APPENDICITIS : A SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 10(1), 77-84. https://doi.org/10.61841/505y3779