THE ASSOCIATION OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES IN ADULTS WITH ATOPIC DERMATITIS: A COMPREHENSIVE SYSTEMATIC REVIEW

Authors

  • Yhoaninda Nurul Ilmi Sultan Agung Islamic University, Semarang, Indonesia
  • Putri Kusuma Wardani Tinspardi Medika Primary Clinic, Trenggalek, Indonesia

DOI:

https://doi.org/10.61841/z2x20p66

Keywords:

Atopic dermatitis, Cardiovascular disease, type 2 diabetes

Abstract

Background: Atopic dermatitis (AD) is one of the most common inflammatory diseases in medicine, associated with a broad patient burden of skin lesions, pruritus, and both allergic and non-allergic comorbidities.

The aim: This study aims to show about the association of cardiovascular disease and type 2 diabetes in adults with atopic dermatitis.

Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.

Result: In the PubMed database, the results of our search brought up 169 articles, whereas the results of our search on SagePub brought up 60 articles. The results of the search conducted for the last year of 2014 yielded a total 41 articles for PubMed and 46 articles for SagePub. The result from title screening, a total 5 articles for PubMed and 20 articles for SagePub. In the end, we compiled a total of 10 papers. We included five research that met the criteria.

Conclusion: The link between AD and other allergic diseases such as food allergies, allergic rhinitis, and asthma is well known. Recently, in addition to allergic diseases, research has been conducted on the relationship between AD and other diseases such as depression, alopecia areata, inflammatory bowel disease, and cardiovascular disease (CVD) and metabolic syndrome like type 2 diabetes.

References

Nishida Y, Kubota Y, Iso H, Tamakoshi A, Tamakoshi A, Mori M, et al. Self-reported eczema in relation with mortality from cardiovascular disease in Japanese: The Japan collaborative cohort study. J Atheroscler Thromb. 2019;26(9):775–82.

Hojman L, Karsulovic C. Cardiovascular Disease-Associated Skin Conditions. 2022;(February):43–53.

Silverberg JI. Associations between atopic dermatitis and other disorders. F1000Research. 2018;7(0):1–9.

Fujiyoshi A. Eczema and risk of cardiovascular disease: Heightened awareness needed. J Atheroscler Thromb. 2019;26(9):760–1.

Lu F, Wu B, Wang Y. Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes. BMC Med Genomics. 2023;16(1):1–10.

Ascott A, Mulick A, Yu AM, Prieto-Merino D, Schmidt M, Abuabara K, et al. Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies. J Allergy Clin Immunol. 2019;143(5):1821–9.

Hedderson MM, Asgari MM, Xu F, Quesenberry CP, Sridhar S, Geier J, et al. Rates of cardiovascular events among patients with moderate-to-severe atopic dermatitis in an integrated health care system: A retrospective cohort study. PLoS One [Internet]. 2022;17(11 November):1–12. Available from: http://dx.doi.org/10.1371/journal.pone.0277469

Brunner PM, Suárez-Fariñas M, He H, Malik K, Wen HC, Gonzalez J, et al. The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins. Sci Rep. 2017;7(1):1–12.

Silverwood RJ, Forbes HJ, Abuabara K, Ascott A, Schmidt M, Schmidt SAJ, et al. Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: Population based cohort study. BMJ. 2018;361.

Smirnova J, Montgomery S, Lindberg M, Svensson Å, von Kobyletzki L. Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study. BMC Dermatol. 2020;20(1):1–10.

Palareti G, Legnani C, Cosmi B, Antonucci E, Erba N, Poli D, et al. Comparison between different D-Dimer cutoff values to assess the individual risk of recurrent venous thromboembolism: Analysis of results obtained in the DULCIS study. Int J Lab Hematol. 2016;38(1):42–9.

Woo YR, Cho M, Han K Do, Cho SH, Lee JH. Atopic Dermatitis and the Risk of Myocardial Infarction and All-Cause Mortality: A Nationwide Population-Based Cohort Study. Allergy, Asthma Immunol Res. 2023;15(5):636–46.

Jung HJ, Lee DH, Park MY, Ahn J. Cardiovascular comorbidities of atopic dermatitis: using National Health Insurance data in Korea. Allergy, Asthma Clin Immunol [Internet]. 2021;17(1):1–9. Available from: https://doi.org/10.1186/s13223-021-00590-x

Chen H, Zhuo C, Zheng L. Assessing Causal Associations of Atopic Dermatitis With Heart Failure and Other Cardiovascular Outcomes: A Mendelian Randomization Study. Front Cardiovasc Med. 2022;9(June):1–8.

Mirghani HO, Alhazmi K, Alghamdi S, Alraddadi M. The Cross-Talk Between Atopic Dermatitis and Diabetes Mellitus: A Meta-Analysis. Cureus. 2021;13(3):10–4.

Downloads

Published

2024-02-20

How to Cite

Nurul Ilmi, Y., & Kusuma Wardani, P. . (2024). THE ASSOCIATION OF CARDIOVASCULAR DISEASE AND TYPE 2 DIABETES IN ADULTS WITH ATOPIC DERMATITIS: A COMPREHENSIVE SYSTEMATIC REVIEW. Journal of Advanced Research in Medical and Health Science (ISSN 2208-2425), 10(2), 155-162. https://doi.org/10.61841/z2x20p66