COMPARISON BETWEEN NEBULISATION OF MGSO4 20 MG/KGBW WITH KETAMINE 0.5 MG/KGBW ON THE INCIDENT OF POST-OPERATIVE SORE THROAT DUE TO ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOING GENERAL ANESTHESIA IN DR. HASAN SADIKIN HOSPITALS BANDUNG
DOI:
https://doi.org/10.61841/7hyssr73Keywords:
General anesthesia, Endotracheal intubation, Ketamine, MgSO4, POST nebulizationAbstract
Post Operative Sore Throat (POST) is a Symptoms often experienced by patients after surgery under general anesthesia and endotracheal intubation. The incidence of POST is between 21-71.8. POST causes discomfort to patients which can prolong hospital stay. In this study, a comparison was made between MgSO4 nebulization 20 mg/ KgBW and ketamine nebulization 0.5 mg/ KgBW on the incidence of POST after general anesthesia at RSUP Dr. Hasan Sadikin Bandung . This study used a double blind randomized controlled trial design. 72 elective surgery patients were randomly divided into 2 groups. Group M was given MgSO4 nebulization while group K was given ketamine nebulization. Nebulization was performed 15 minutes before induction of general anesthesia. POST monitoring was performed at 1, 4 and 24 hours after extubation using POST scoring. In this study, it was found that the incidence of POST in group M, namely the 1st hour of 13.5, the 4th hour of 10.8 and the 24th hour of 0 was lower than that in group K, namely the 1st hour of 28.5, the 4th hour of 32.5 and the 24th hour of 0. Statistical test results p0.033 showed a significant difference in group M better than group K at the 4th hour in reducing the incidence of POST. MgSO4 and ketamine have antinociceptive and anti-inflammatory effects with the mechanism of action of blocking NMDA receptors that inhibit calcium influx that avoids central sensitization. MgSO4 also has a muscle relaxing effect and reduces airway mucus secretion, thus reducing the risk of trauma during endotracheal intubation. The conclusion of this study is that MgSO4 nebulization shows a lower incidence of POST than ketamine nebulization.
References
Kumar GB, Balakrishnan M, Ramesh B. The Effect of Nebulized Magnesium Sulphate on the Incidence of Postoperative Soret Throat. AAI. 2020; Vol 5(1):185–90.
Barash PG. Clinical Anesthesia. Edisi Ke 8. Philadelphia: Wolters Kluwer Health. 2017: Section 8; Halaman 1901–2004.
Padma T, Raju B, Raviraj GS. The Effect of Nebulized Magnesium Sulphate on the Incidence of Postoperative Sorethroat. AAI. 2020; Vol5(1):185–90.
Millizia A, Maulina F. Hubungan Nyeri Tenggorok Dan Faktor Risiko Pasien Pasca Operasi Dengan Anestesi Umum Intubasi Endotrakeal di BLUD RSU Cut Meutia Aceh Utara. JKKM. 2018; Vol 4(2):46.
Aigbedia SO, Tobi KU, Amadasun FE. A Comparative Study of Ketamine Gargle and Lidocaine Jelly Application for the Prevention of Postoperative Throat Pain Following General Anaesthesia With Endotracheal Intubation. NJC. 2017; Vol 20(6): 677.
Fenta E, Teshome D, Melaku D, Tesfaw A. Incidence and factors associated with postoperative sore throat for patients undergoing surgery under general anesthesia with endotracheal intubation at Debre Tabor General Hospital, North central Ethiopia: A cross-sectional study. IJSO. 2020; 25:1–5.
Edomwonyi NP, Ekwere IT, Omo E, Rupasinghe A. Postoperative throat complications after tracheal intubation. Ann Afr Med. 2006; Vol5(1):28–32.
El-Boghdadly K, Bailey CR, Wiles MD. Postoperative sore throat: A systematic review anaesthesia. TAAGBI. 2016;71(6):706–17.
Arianto AT, Santosa SB, Anindita A. Comparison of Magnesium Sulfat Gargle and Ketamine Gargle on The Incidence of Sore Throat and Cough After Extubation. SOJA. 2022;2(1):23.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Reza Widianto Sudjud, Muchammad Erias Erlangga, Diki Akbar
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.