The Early Prognosis Value of Activin A in Premature Infants’ Brain Injury
DOI:
https://doi.org/10.53555/nnmhs.v3i3.622Keywords:
Activin A, severity levels, preterm neonates, intraventricular hemorrhage, periventricular leukomalaicaAbstract
The purpose of this research is to explore the predictive value of amniotic fluid, umbilical cord blood and neonatal blood activin A in early brain injury in preterm neonates. 98 cases of premature infants were divided into brain injury group and control group according to the cranial imaging examination, and the brain injury group was further divided into mild brain injury group and severe brain injury group. The activin A level was measured in both preterm brain injury group and control group with enzyme-linked immunosorbent assay (ELISA) kit, then the comparisons of activin A levels between brain injury group and control group, mild and severe brain injury group were implemented to find out their differences. The results demonstrated that activin A levels of umbilical cord blood, amniotic fluid and 3-day-old premature infant peripheral blood in brain injury group were significantly higher than the control group (P<0.05), activin A levels of amniotic fluid, umbilical cord blood and 3-day-old infant blood in the severe brain injury group were significantly higher than the mild brain injury group (P<0.05), intragroup comparison among the brain injury group showed amniotic fluid and 3-day-old premature infant serum activin A levels were significantly higher than umbilical cord blood (P<0.05), activin A has a certain value in early prediction and severity assessment of preterm brain injury.
References
Florio P., Gazzolo D., Luisi S., Petraglia F., Activin A in brain injury, 2007
He J. T., Mang J., Mei C. L., Yang L., Wang J. Q., Xing Y., et al., Neuroprotective effects of exogenous activin A on oxygen-glucose deprivation in PC12 cells, 2012
Mukerji S. S., Katsman E. A., Wilber C., Haner N. A., Selman W. R., Hall A. K., Activin is a neuronal survival factor that is rapidly increased after transient cerebral ischemia and hypoxia in mice, 2007
Boyce, G.C., Smith, T.B., & Casto, G., Health and educational outcomes of children who experienced severe neonatal medical complications, 1999
Whitaker, A.M., Feldman, J.F., Van Rossem, R., Schonfeld, I.S., Pinto-Martin, J.A.,Torre, C., et al., Neonatal cranial ultrasound abnormalities in low birth weight infants: Relation to cognitive outcomes at six years of age, 1996
Wilson-Costello D., Friedman H., Minich N., Fanaroff A. A., Hack M., Improved survival rates with increased neural developmental disability for extremely low birth weight infants, 2005
Volpe, J.J., 2001a. Intracranial hemorrhage: germinal matrix-intraventricular hemorrhage, 2001a
Volpe, J.J., Neurology of the Newborn, 2001b
Bassan, H., Intracranial hemorrhage in the preterm infant: understanding it, preventing it, 2009
Hack, M., Wilson-Costello, D., Friedman, H., Taylor, H.G., Schlucter, M., & Fanaroff, A.A. Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000 g: 1992-1995, 2000
Boyce, G.C., Smith, T.B., & Casto, G. Health and educational outcomes of children who experienced severe neonatal medical complications, 1999
O’Shea, T.M., Klinepeter, K.L., Meis, P.J., Dillard, R.G., Intrauterine infection and the risk of cerebral palsy in very low-birth weight infants,1998
Holcroft, C.J., Blakemore, K.J., Allen, M., Graham, E.M. Association of prematurity and neonatal infection with neurologic morbidity in very low birth weight infants, 2003
Graham, E.M., Holcroft, C.J., Rai, K.K., Donohue, P.K., Allen, M.C. Neonatal cerebral white matter injury in preterm infants is associated with culture positive infections and only rarely with metabolic acidosis, 2004
Whitaker, A.M., Johnson, J., Sebris, S., Pinto, J., Wasserman, G., Kairam, R., et al. Neonatal cranial ultrasound abnormalities: association with developmental delay at age one in low birth weight infants, 1990
Volpe J. J., Kinney H. C., Jensen F. E., Rosenberg P. A. The developing oligodendrocyte: key cellular target in brain injury in the premature infant, 2011
Bouvier D., Castellani C., Fournier M., Dauphin J. B., Ughetto S., Breton M., et al. Reference ranges for serum S100B protein during the first three years of life, 2011
Bass W.T, Periventricular leukomalacia, 2011
Galli K. K., Zimmerman R. A., Jarvik G. P., Wernovsky G., Kuypers M. K., Clancy R. R., et al.Periventricular leukomalacia is common after neonatal cardiac surgery, 2004
Gazzolo D., Bruschettini M., Corvino V., Lituania M., Sarli R., Bruschettini P., et al. . Amniotic fluid levels of S100B protein in normal and trisomy-21, 2003a
L. An, X.Y Wang, J.Wu Protective effects of activin on the neurons of neonatal rats with hypoxic ischemic brain injury, 2006
Sutton, P.S., Darmstadt, G.L. Preterm birth and neurodevelopment: a review of outcomes and recommendations for early identification and cost-effective interventions, 2013
Petraglia F, Garuti GC, Calza' Let al. lnhibin subunits in human placenta: localization and messenger ribonucleic acid levels during pregnancy, l991
Wallace EM, Riley SC, Crossley JA et al. Dimeric inhibins in amniotic fluid, maternal serum and fetal serum in human pregnancy,1997
Petraglia F, Gag S, Florio Pet al. Activin A and activin B measured in maternal serum,cord blood serum and in amniotic fluid during human pregnancy,1993
Muttukrishna S, Fowler PA, George L, Grmme NP, Knight PG. Changes in peripheral serum levels of total activin A during menstrual cycle and pregnancy,1996
Petraglia F, Luisi S, Benedetto C et al. Changes of dimeric inhibin B levels in maternal serum throughout healthy gestation and in women with gestational diseases, 1997
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Licensing
Ninety Nine Publication publishes articles under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This licensing allows for any use of the work, provided the original author(s) and source are credited, thereby facilitating the free exchange and use of research for the advancement of knowledge.
Detailed Licensing Terms
Attribution (BY): Users must give appropriate credit, provide a link to the license, and indicate if changes were made. Users may do so in any reasonable manner, but not in any way that suggests the licensor endorses them or their use.
No Additional Restrictions: Users may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.