SEROPREVALENCE OF THE HUMAN IMMUNODEFICIENCY VIRUS AND IMPACT ON FERTILITY IN COUPLES AT THE GYNAECOLOGICAL ENDOSCOPIC SURGERY AND HUMAN REPRODUCTIVE TEACHING HOSPITAL, CAMEROON
DOI:
https://doi.org/10.53555/nnpbs.v8i4.1207Keywords:
HIV, infertility, tubo-ovarian union, oligospermia, GESHRTH, CameroonAbstract
Introduction: HIV biology may explain subfertility in infected patients. The objective of our study was to evaluate the impact of HIV infection on the male and female fertility of couples followed at the Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital (GESHRTH).
Methodology: an analytical cross-sectional study was conducted over a period of 9 months from January 1st to September 1st, 2019 at the GESHRTH. A total of 279 complete files were included in our study consecutively. The qualitative variables were compared using a Chi² test or Fisher’s exact test using Epi Info software version 3.5.4 with a statistically significant threshold, p<5%.
Results: The most represented female morphological abnormalities were tubo-ovarian adhesions, i.e. 48.4% (135), followed by uterine fibroids, i.e. 32.2% (90). Concerning men, 50.9% (142) had spermogram abnormalities among which oligospermia (42.7%) was mainly found. HIV seroprevalence was higher in women (36; 12.9%) than in men (12; 4.3%). The type of infertility and the morphological etiologies of female infertility were not related to HIV infection. On the other hand, all HIV-positive men (100%) had a sperm abnormality which was oligospermia (p < 0.001).
Conclusion: HIV could have an impact on the occurrence of sperm abnormalities including oligospermia. However, prospective studies should be conducted to further investigate the impact of HIV on fertility.
References
UNAIDS, Fact Sheet — Latest statistics on the state of the AIDS epidemic. GLOBAL HIV STATISTICS. https://www.unaids.org/en/resources/fact-sheet (accessed December 21, 2021)
National Institute of Statistics (INS), Republic of Cameroon. Demographic and Health Survey 2018, Ref. CMR_2018_DHS_v01_M. Data downloaded from https://www.dhsprogram.com/what-we-do/survey/survey-display-511.cfm (accessed August 26, 2021).
Agboghoroma CO, Giwa-Osagie OF. Management of infertility in HIV infected couples : a review. Afr J Reprod Health. 2012 Dec ;16(4) :13-20.
Nana PN, Wandji JC, Fomulu JN, Mbu RE, Leke RJI, Woubinwou MJ. Psycho-Social Aspects in Infertile Patients at the Main Maternity Unit of the Central Hospital of Yaounde, Cameroon, Clinics in Mother and Child Health Vol. 8 (2011).
Saleem HT, Rosen JG, Quinn C, Duggaraju A, Kennedy CE. Contraception values and preferences of people living with HIV : A systematic review. Contraception. 2021 Nov 5 :S0010-7824(21)00433-9.
Kushnir V.A., Lewis W., HIV/AIDS and Infertility : Emerging Problems in the Era of Highly Active Antiretrovirals. Fertil Sterile. 2011 ; 96(3) :546-53.
Garolla A, Pizzol D, Bertoldo A, Menegazzo M, Barzon L, Foresta C. Sperm viral infection and male infertility : focus on HBV, HCV, HIV, HPV, HSV, HCMV, and AAV. J Reprod Immunol. 2013 Nov ;100(1) :20-9.
Frapsauce C, Grabar S, et al, Impaired sperm motility in HIV-infected men : an unexpected adverse effect of efavirenz ? Hum Reprod Oxf Engl. 2015 ; 30(8) :1797-806.
Shevchuk MM, Pigato JB, et al, Changing testicular histology in AIDS : its implication for sexual transmission of HIV, Urology. 1999 Jan ; 53(1) :203-8.
Clark RA, Brandon W, et al, Clinical manifestations of infection with the human immunodeficiency virus in women in Louisiana, Clin Infect Dis 1993 ; 17 :165-72.11.
Adedigba JA, Idowu BM, Hermans SP, Ibitoye BO, Fawole OA. The relationship between hysterosalpingography findings and female infertility in a Nigerian population. Pol J Radiol. 2020 Apr 13 ;85 :e188-e195.
Abebe MS, Afework M, Abaynew Y. Primary and secondary infertility in Africa : systematic review with meta-analysis. Fertil Res Pract. 2020 Dec 2 ;6(1) :20.
Colson, Marie-Helene. « Sexuality and pathologies of aging in elderly men and women », Gérontologie et société, vol. 35/140, no. 1, 2012, p. 109-130.
Brandt JS, Cruz Ithier MA, Rosen T, Ashkinadze E. Advanced paternal age, infertility, and reproductive risks : A review of the literature. Prenat Diagn. 2019 Jan ;39(2) :81-87.
Matumo P, Bunduki G, Kamwira IS, Sihalikyolo J, Bosunga K. Spermogram abnormalities in premarital consultations and in infertile couples in Butembo, Democratic Republic of Congo [Abnormal semen analyzes in men undergoing premarital screening and in infertile couples in Butembo -Democratic Republic of Congo]. Pan Afr Med J. 2020 Oct 13 ;37 :155.
Nguyen PV, Kafka JK, Ferreira VH, Roth K, Kaushic C. Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection. Cell Mol Immunol. 2014 Sep ;11(5) :410-27.
James DM Nicopoullos, Paula A Almeida, Jonathan WA Ramsay, Carole Gilling-Smith, The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing, Human Reproduction 19 (10), 2289-2297, 2004.
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