COMORBIDITIES AND COVID-19 SEVERITY IN PEDIATRIC PATIENTS: SYSTEMATIC REVIEW
DOI:
https://doi.org/10.53555/nnpbs.v9i2.1530Keywords:
Comorbidities, COVID-19, Obesity, Pediatric, Severity.Abstract
There is inconsistency between the findings of the several research that have been conducted about the association between comorbidities and the severity of pediatric COVID-19. A fundamental disadvantage of the studies that are now available is that they do not provide sufficient information on the clinical presentation and results. The majority of research characterize the severity of COVID-19 merely by reporting admission or fatality rates from critical care units. Severe disease is uncommon in children as compared to adults, and the majority of studies reflect the severity of the disease (ICUs). Infections caused by SARS-CoV-1 and MERS-CoV, as well as adult corona virus disease 2019 (COVID-19), comorbidities that were already present at the time of infection are regarded to be a risk factor for more severe disease. The majority of studies point to a connection between obesity and the outcomes of COVID-19 patients, and this is true for both children and adults. Some experts have put forward a theory as to why children are not susceptible to COVID-19 is that because children are often exposed to the other four mild coronaviruses that circulate each year and cause the common cold. This provides a boost in immunity in children, but many dispute that argument because adults also get the common cold virus and children's immune systems especially children <5 years are still underdeveloped which should make them more vulnerable.
References
Gorbalenya AE. Severe acute respiratory syndrome-related coronavirus – The species and its viruses, a statement of the Coronavirus Study Group. BioRxiv. 2020;2(7):93–7.
Rivers C. Coronavirus is mysteriously sparing kids and killing the elderly. Understanding why may help defeat the virus [Internet]. Washingtnpost.com. 2020. Available from: https://www.washingtonpost.com/health/2020/03/10/coronavirus-is-mysteriously-sparing-kids-killing-elderly-understanding-why-may-help-defeat-virus/
Centers for Disease Control and Prevention. 2019 Novel Coronavirus (2019-nCoV). Washington DC; 2020.
Zimmermann P; Curtis N. Coronavirus Infections in Children Including COVID-19. Pediatr Infect Dis J. 2020;39(5):355–69.
Rajapakse N, Dixit D. Human and novel coronavirus infections in children: a review. Paediatr Int Child Health. 2021;41(1):36–55.
Jain V, Yuan J-M. Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis. Int J Public Health. 2020 Jun;65(5):533–46.
Nakra NA, Blumberg DA, Guerra AH, et al. Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management. Child. 2020;7(7):69.
Biharie A, Keuning MW, Wolthers KC, Pajkrt D. Comorbidities, clinical characteristics and outcomes of COVID-19 in pediatric patients in a tertiary medical center in the Netherlands. Vol. 18, World journal of pediatrics?: WJP. Switzerland; 2022. p. 558–63.
Drouin O, Hepburn CM, Farrar DS, Baerg K, Chan K, Cyr C, et al. Characteristics of children admitted to hospital with acute SARS-CoV-2 infection in Canada in 2020. C Can Med Assoc J = J l’Association medicale Can. 2021 Sep;193(38):E1483–93.
Bellino S, Punzo O, Rota MC, Del Manso M, Urdiales AM, Andrianou X, et al. COVID-19 Disease Severity Risk Factors for Pediatric Patients in Italy. Pediatrics. 2020 Oct;146(4).
Swann O V, Holden KA, Turtle L, Pollock L, Fairfield CJ, Drake TM, et al. Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ. 2020 Aug;370:m3249.
Martin B, DeWitt PE, Russell S, Anand A, Bradwell KR, Bremer C, et al. Characteristics, Outcomes, and Severity Risk Factors Associated With SARS-CoV-2 Infection Among Children in the US National COVID Cohort Collaborative. JAMA Netw Open [Internet]. 2022 Feb 8;5(2):e2143151–e2143151. Available from: https://doi.org/10.1001/jamanetworkopen.2021.43151
Gorbalenya A, Baker S, Baric R, de Groot R, Drosten C, Gulyaeva A, et al. Severe acute respiratory syndrome-related coronavirus?: The species and its viruses – a statement of the Coronavirus Study Group. Nat Microbiol. 2020 Feb;2020.02.07.937862.
Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(6).
Riphagen S, Gomez X, Gonzales-Martinez C, et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;
Leven Y, Bösel J. Neurological manifestations of COVID-19 - an approach to categories of pathology. Neurol Res Pract. 2021 Jul;3(1):39.
Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–4.
Ludvigsson JF. Systematic review of COVID?19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020;109(6):1088–95.
Brodin P. Immune determinants of COVID-19 disease presentation and severity. Nat Med. 2021;27(1):28–33.
Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. Vol. 382, The New England journal of medicine. United States; 2020. p. 1177–9.
Royal College of Paediatrics and Child Health. Guidance: paediatric multisystem inflammatory syndrome temporarily associated with COVID- 19 [Internet]. Royal College of Paediatrics and Child Health. 2020. Available from: https://www.rcpch.ac.uk/resources/g uidance-paediatric-multisystem- inflammatory-syndrome-temporally- associated-covid-19-pims
Zhou Y, Chi J, Lv W, Wang Y. Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19). Diabetes Metab Res Rev. 2021 Feb;37(2):e3377.
Nogueira-de-Almeida CA, Del Ciampo LA, Ferraz IS, Del Ciampo IRL, Contini AA, Ued F da V. COVID-19 and obesity in childhood and adolescence: a clinical review. J Pediatr (Rio J). 2020;96(5):546–58.
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