Evaluation of Antianxiety Activity of Bauhinia variegata in Mice
DOI:
https://doi.org/10.53555/nnpbs.v2i2.717Keywords:
Anxiety, Bauhinia variegata, Buspirone, Keywords: Anxiety, Bauhinia variegata, Buspirone,Abstract
Bauhinia variegata has been used traditionally to treat bronchitis, leprosy and tumors. The present study was designed to evaluate the anti-anxiety activity of the leaves and seeds of Bauhinia variegata using elevated plus maze (EPM) model in Swiss albino mice. Albino mice were treated orally with different doses of the extracts (i.e.100, 200 mg/kg) and behavior was observed on the EPM. Buspirone (6mg/kg, p.o) was used as a positive control. Results show that methanol extract at the dose of 100mg/kg of the leaves of Bauhinia variegata and B. variegata seeds (200 mg/kg) markedly increased the average time spent in the open arms of the EPM. This effect was comparable to the effect produced by Buspirone. Hence this plant may be developed as a potentially useful anti anxiety agent.
References
Evans, D.L., Charney, D.S., Lewis, L., Golden, J.M., Krishnan, K.R.R. and Nemeroff C.B. 2005. Mood disorders in the medically ill: Scientific review and recommendations, Biol. Psychiatry, vol. 58, 175–189.
Gureje, O., Von, Korff, M., Simon, G.E. and Gater, R., 1998. Persistent pain and well-being: A World Health Organization study in primary care, JAMA, vol. 280, 147–151.
Masoumeh, E., Mohammad, K. and Maryam, F.A., 2005. Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze, J. Ethnopharmacol., vol. 96, 365-370.
Spinella, M., 2001. Herbal Medicines and Epilepsy: The Potential for Benefit and Adverse Effects, Epilepsy Behav., vol. 2, 524-532.
Patil, J. K., Patel, M. R., Sayyed, H. Y. et al, 2012. Pharmacognostic and phytochemical investigation of Bauhinia variegata (linn.) Benth. Stem bark. Pharma science monitor, vol. 3(1), 1-12.
Ambasta, S.P., 1998. The wealth of India, Raw materials, vol. 2, 56-7.
Ram, P.R., Mehrotra, B.N., 1980. In: Compendium of Indian medicinal plants, vol. 3, 84-91.
Gopala Krishna, H.N., Sangha, R.B., et al. 2006. Anti-anxiety activity of NR-ANX-C, polyherbal preparation in rats. Indian Journal of Pharmacology vol. 38, 330-335.
Kumar, S. and Sharma, A., 2005. Anti-anxiety activity studies of various extracts of Turnera aphrodisiaca Ward., J. Herb. Pharmacother., vol. 5, 13-21.
Gupta, V., Bansal, P., Niazi, J., Kaur, G., 2010. Anti-anxiety Activity of Citrus paradisi var. star ruby Extracts, International Journal of PharmTech Research, vol.2 (3), 1655-1657.
Wolfman, C., Viola, H., Paladini, A., Dajas, F. and Medina, J.H., 1994. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea, Pharmacol. Biochem. Behav., vol. 47, 1-4.
Medina J.H., Viola H., Wolfman C., Marder M., Wasowski C., Clavo D. and Paladini A.C., Neuroactive flavonoids: new ligands for the benzodiazepine receptors, Phytomed., 1997, 5, 235-243.
Griebel G., Perrault G., Tan S., Schoemaker H. and Sanger D.J., Pharmacological studies on synthetic flavonoids: comparison with diazepam, Neuropharmacol., 1999, 38, 965.
Paladini A.C., Marder M., Viola H., Wolfman C., Wasowski C. and Medina J.H., Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds, J. Pharm.Pharmacol., 1999, 51, 519-526.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Terms & Condition
Submission -
Author can submit the manuscript through our online submission process or email us at the designated email id in contact details.
The other mode of submission not accepted than online and email.
Before submission please read the submission guidelines.
NN Publication accepts only article submitted in pdf/doc/docx/rtf file format. Another format except given file formats will no be considered .
Author will be responsible for the error mistakes in the submission files. The minor changes can be done without any cost after publication. But for major changes NN Publication may charges you the editing charges.
Publication (Online) -
The online publication is scheduled on last date of every month, but it can be delayed by 24 to 48 hours due to editorial process if huge number of articles comes to publish in single issue.
Automatic notificatation email will be sent to the all users on publication of an issue, so its author’s duty to check their email inbox or SPAM folder to get this notification.
After publication of article author can not withdraw their article.
If editor’s found any issue after publication of article then the NN Publication have the authority to remove the article from online website.
No refund will be provided after online publication of article.
Publication (Print) -
The print copy publication are sent as per the author’s request after 2 weeks of online publication of that issue.
NN Publication will ship the article by India Post and provide the consignment number on dispatch of print copy.
NN Publication follows all the guidelines of delivery provided by IndiaPost and hence not responsible for delay in delivery due to any kind of reasons.
Refund of hard copy will not be provided after dispatch or print of the journal.
NN Publication will be responsible for raise a complain if there is any issue occurs in delivery, but still will not be responsible for providing the refund.
NN Publication will be responsible to resend the print copy only and only if the print copy is lost or print copy is damaged in delivery / or there is delay more than 6 months.
According to India Post the delivery should be completed with in 1-3 weeks after dispatch of articles.
Privacy Policy-
NN Publication uses the email ids of authors and editors and readers for sending editorial or publication notification only, we do not reveal or sell the email ids to any other website or company.
