Dual role of RNase A and Metosartan - Examination in invitro &invivo condition

  • Eswari Beeram PhD, Venkateswara University
Keywords: Metoprolol, Netosis, Uncompetitive inhibition, DNA adducts, Cyt P450

Abstract

Metosartan consists of two components Metoprolol and telmisartan. Telmisartan inhibits RNase A in rat testes by uncompetitive inhibition where as Metoprolol forms DNA adducts and reduces sperm count. Metosartan decreases testes viability and sperm count was found to be high in metosartan treated rats compared to Metosartan +RNase A group. RNase A induces Netosis in both invivo and invitro condition in both RNase treated group and as well as RNase A+ Metosartan. Deep cold storage of mitochondria induces expression of cyt P450gene in testes mitochondria but not in sperm.

Author Biography

Eswari Beeram, PhD, Venkateswara University

hD, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
Assistant Professor, Department of chemical sciences, Sree Vidyanikethan Degree college,
Tirupati, Andhra Pradesh, India.

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Published
2019-06-06
How to Cite
Beeram, E. (2019). Dual role of RNase A and Metosartan - Examination in invitro &invivo condition. Journal of Advance Research in Pharmacy & Biological Science (ISSN: 2208-2360), 5(5), 01-09. Retrieved from https://nnpub.org/index.php/PBS/article/view/742